摘要
目的:观察活血消癥方加减应用于异位妊娠患者中的临床效果,并观察其对患者血清激素水平及其炎性指标的影响。方法:选取异位妊娠患者(n=60)为研究对象,依据双盲法,将入选患者分成观察组与对照组,其中对照组(n=30)行甲氨蝶呤联合米非司酮治疗,观察组(n=30)在对照组治疗基础上行活血消癥方加减治疗。观察两组患者的疗效、不良反应、治疗前后的血清激素及炎性指标水平。结果:观察组无效1例,总有效率96.67%,对照组无效10例,总有效率66.67%,观察组总有效率高于对照组(P<0.05);两组包块、腹痛、阴道出血消失时间及血清β-HCG恢复正常值时间对比,观察组均明显短于对照组(P<0.05);治疗前,两组患者β-HCG、孕酮、E 2水平比较,差异均无统计学意义(P>0.05);治疗后,两组均有所降低,且观察组明显低于对照组(P<0.05);且经治疗,观察组CRP及IL-6水平下降低于对照组,差异均具有统计学意义(P<0.05);观察组及对照组不良反应总发生率为16.67%、53.33%,两组比较差异有统计学意义(P<0.05)。结论:异位妊娠患者采用活血消癥方加减联合西药治疗效果明显,可降低患者血清激素水平,缩短临床症状消失时间,抑制炎症反应,且不良反应少。
Objective:To observe the clinical effect of Huoxue Xiaozheng recipe applied to patients with ectopic pregnancy,and to observe its effect on serum hormone levels and inflammatory indicators.Methods:The ectopic pregnancy patients(n=60)were selected as the research object.According to the double-blind method,the selected patients were divided into an observation group and a control group,of which the control group(n=30)treatment with methotrexate combined with mifepristone,observation group(n=30)added Huoxue Xiaozheng recipe addition and subtraction treatment on the basis of the control group observe the efficacy,adverse reactions,serum hormone levels and inflammatory index levels of the two groups of patients before and after treatment.Results:One case was ineffective in the observation group,with a total effective rate of 96.67%,and 10 cases were ineffective in the control group,with a total effective rate of 66.67%.The total effective rate in the observation group was higher than that in the control group(P<0.05).The disappearance time of vaginal bleeding and the time for serumβ-HCG to return to normal value,the observation group was significantly shorter than the control group(P<0.05).Before treatment,the levels ofβ-HCG,progesterone and E 2 in the two groups were not statistically significant(P>0.05).After treatment,both groups decreased,and the observation group was significantly lower than the control group(P<0.05).After treatment,the observation group CRP and IL-6 levels fell lower than the control group,with statistics Significance(P<0.05);The total incidence of adverse reactions in the observation group and the control group was 16.67%and 53.33%,compared between the two groups(P<0.05).Conclusion:The treatment of ectopic pregnancy patients with Huoxue Xiaozheng recipe combined with western medicine has obvious effect,which can reduce the serum hormone levels,shorten the disappearance time of clinical symptoms,inhibit inflammation,and have fewer adverse reactions.
作者
杜倩
王浜
吴晶晶
DU Qian;WANG Bang;WU Jingjing(Huaibei People’s Hospital,Huaibei 235000,China)
出处
《陕西中医》
CAS
2021年第4期430-433,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(81704074)。
关键词
活血消癥方
异位妊娠
临床症状
血清激素
炎症因子
不良反应
Huoxue Xiaozheng recipe
Ectopic pregnancy
Clinical symptoms
Serum hormones
Inflammatory factors
Adverse reactions
