摘要
过敏性紫癜(HSP)是儿童时期常见的系统性小血管炎,近年来发病率逐渐上升,影响儿童的身心健康。由于伦理的限制,HSP病因、发病机制及优化治疗方案的深入研究需要动物模型的构建,但国内外缺乏成熟的HSP动物模型,笔者就目前HSP动物模型的造模方法、优缺点及异同点等进行综述,为相关的科研人员提供参考。
Henoch-Schonlein purpura(HSP)is a common systemic vasculitis in childhood.The incidence rate of children gradually increases in recent years,which affects the physical and mental health of children.Due to ethical limitations,the in-depth study of the etiology,pathogenesis and optimal treatment of HSP needs the construction of animal models,but there is no mature HSP animal models in china and abroad.The author summarized the current methods,advantages and disadvantages,similarities and differences of HSP animal models,so as to provide reference for relevant researchers.
作者
徐闪闪
王龙
张霞
丁樱
白明晖
XU Shan-shan;WANG Long;ZHANG Xia;DING Ying;BAI Ming-hui(Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Affiliated Hospital of Henan University of CM,Zhengzhou 450000,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2021年第3期1539-1542,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金面上项目(No.81873343)
河南中医药大学特色优势学科项目(No.STS-ZYX-2017008)。
关键词
过敏性紫癜
动物模型
研究进展
病理模型
病证结合模型
Henoch-Schonlein purpura(HSP)
Animal model
Research progress
Pathological model
Model of combination of disease and syndrome
