摘要
目的:探讨在新生儿ABO溶血性黄疸中应用丙种球蛋白的适宜胆红素水平。方法:采用回顾性研究方法,选取我院新生儿科于2016年6月至2018年2月收治的新生儿ABO溶血性黄疸患儿160例,根据是否应用丙种球蛋白分为试验组和对照组各80例。按新生儿小时胆红素列线图(Bhutani曲线)的低危区、低中危区、高中危区、高危区,分别比较住院时间、光疗时间、治疗后每小时胆红素下降值,分析应用丙种球蛋白的适宜胆红素水平范围。结果:在高危区及高中危区,试验组患儿的住院时间、光疗时间均短于对照组,治疗后每小时胆红素下降值大于对照组(P均<0.05);在低中危区及低危区,试验组患儿的住院时间、光疗时间及治疗后每小时胆红素下降值与对照组比较差异均无统计学意义(P均>0.05)。结论:当新生儿血胆红素水平在Bhutani曲线中处于高中危区及以上时,予以丙种球蛋白治疗更为合适。
Objective:To probe into the appropriate bilirubin level of gamma globulin in neonates with ABO hemolytic jaundice.Methods:Retrospective analysis was adopted,160 cases of neonatal ABO hemolytic jaundice admitted to neonatology department from Jun.2016 to Feb.2018 were extracted to be divided into the experimental group and the control group according to the application of gamma globulin,with 80 cases in each group.According to the low-risk area,low-medium-risk area,high-medium-risk area and highrisk area of the neonatal hour-specific bilirubin nomogram(Bhutani curve),the length of stay,the duration of phototherapy and the decrease of bilirubin per hour after treatment were compared respectively,and the appropriate bilirubin level for gamma globulin was analyzed.Results:In the high-risk area and high-medium-risk area,the length of stay and the total duration of phototherapy in the experimental group were shorter than those in the control group,and the decrease of bilirubin per hour after treatment was greater than that of the control group(P<0.05).In the low-medium-risk area and low-risk area,there was no statistical significant difference in the length of stay,the total duration of phototherapy and the decrease of bilirubin per hour after treatment between two groups(P>0.05).Conclusion:When bilirubin level is in the high-medium-risk area on Bhutani curve,gamma globulin therapy is more appropriate.
作者
丁小燕
田鹏
白静
Ding Xiaoyan;Tian Peng;Bai Jing(Sichuan Nanchong Central Hospital,Sichuan Nanchong 637000,China)
出处
《儿科药学杂志》
CAS
2021年第4期28-30,共3页
Journal of Pediatric Pharmacy
