摘要
细胞黏附分子-1(intercellular adhesion molecule-1,ICAM-1)是存在于细胞膜上的一种具有多类效应的糖蛋白,可介导细胞间的趋化和黏附。ICAM-1可与肝脏内皮细胞膜表面相对应的受体结合,使内皮细胞通透性上升并分泌大量介质,促使细胞间的聚集,进而提高炎性细胞与内皮细胞间的黏附效应。近期研究表明,ICAM-1诱发及加重胆汁淤积的机制与ICAM-1同炎性因子、巨噬细胞分子(molecular-1,Mac-1)/淋巴功能相关抗原1(lymphocyte functional antigen-1,LFA-1)以及钠/氢交换调节因子-1(Na+/H+exchange regulator factor 1,NHERF-1)/埃兹蛋白-根蛋白-膜突蛋白(ezrinradixin-moesin,ERM)的相互作用有关。ICAM-1的表达与各类原因所致的胆汁淤积症严重程度密切相关,可在一定程度上反映胆汁淤积炎症因子的活动程度和肝细胞受损程度,大量研究表明ICAM-1在人类胆汁淤积相关疾病和动物胆汁淤积模型中均高表达。本文从ICAM-1在胆汁淤积发生发展过程中的作用及意义进行综述。
Intercellular adhesion molecule-1(ICAM-1)is a kind of glycoprotein with many kinds of effects on cell membrane,which can mediate chemotaxis and adhesion between cells.ICAM-1 can bind to the corresponding receptors on the surface of hepatic endothelial cells,which can increase the permeability of endothelial cells and secrete a large number of mediators and promote cell aggregation,thereby enhancing the adhesion effects between inflammatory cells and endothelial cells.Recent studies showed that the mechanism of ICAM-1 inducing and aggravating cholestasis was related to the interaction among ICAM-1,inflammatory factors,molecular-1(Mac-1)/lymphocyte functional antigen-1(LFA-1)and Na+/H+exchange regulator factor 1(NHERF-1)/ezrin-radixin-moesin(ERM).The expression of ICAM-1 is closely related to the severity of cholestasis caused by various causes,which reflects the degree of cholestasis inflammatory factors activity and hepatocyte damage to a certain extent.A large number of studies showed that ICAM-1 was highly expressed in human cholestasis-related diseases and animal cholestasis models.This article reviewed the role and significance of ICAM-1 on the occurrence and development of cholestasis.
作者
李晓玲
孙凤霞
Li Xiaoling;Sun Fengxia(Department of Infectious Diseases,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)
出处
《中国肝脏病杂志（电子版）》
CAS
2021年第1期22-26,共5页
Chinese Journal of Liver Diseases：Electronic Version
基金
国家自然科学基金面上项目(81573897)
北京市属医院科研培育计划项目(PZ2018023)。
