摘要
目的采用Meta分析对比药物涂层球囊(DCB)与普通球囊成形术(POBA)治疗股腘动脉闭塞性疾病效果差异。方法检索中国知网、Pubmed、EMBASE、the Cochrane Central Register of Controlled Trials和ISI Web of Knowledge数据库自建库至今DCB与POBA治疗股腘动脉闭塞性疾病的随机对照研究。以R软件对结局指标进行Meta分析,包括晚期管腔丢失(LLL)、再狭窄、靶病变血运重建(TLR)、截肢和死亡。结果共入选18篇文献,DCB组1400例,POBA组1002例;组间LLL[MD=-0.98,95%CI(-1.11,-0.86),P<0.001]、再狭窄[RR=0.33,95%CI(0.27,0.42),P<0.001]和TLR[RR=0.44,95%CI(0.36,0.55),P<0.001]差异均有统计学意义,截肢[RR=0.57,95%CI(0.30,1.09),P=0.091]和死亡[RR=0.70,95%CI(0.39,1.23),P=0.210]差异无统计学意义。结论DCB用于治疗股腘动脉闭塞性疾病整体效果优于POBA。
Objective To compare the difference of drug-coated balloon(DCB)and plain old balloon angioplasty(POBA)in treatment of femoral popliteal artery occlusive diseases with meta analysis.Methods Published literature of CNKI,PubMed,EMBASE,the Cochrane Central Register of Controlled Trials and ISI Web of knowledge databases for randomized controlled trials of DCB and POBA in treatment of femoral popliteal artery occlusive disease were searched from the establishment to now.Meta analysis was performed with R software.The main outcome measures included late lumen loss(LLL),restenosis,target lesion revascularization(TLR),amputation and death.Results Totally 18 articles were enrolled,including 1400 cases in DCB group and 1002 cases in POBA group.There were significant differences of LLL(MD=-0.98,95%CI[-1.11,-0.86],P<0.001),restenosis(RR=0.33,95%CI[0.27,0.42],P<0.001)and TLR(RR=0.44,95%CI[0.36,0.55],P<0.001)between DCB group and POBA group,while no difference of amputation(RR=0.57,95%CI[0.30,1.09],P=0.091)nor death(RR=0.70,95%CI[0.39,1.23],P=0.210)was found between groups.Conclusion DCB was better than POBA in treatment of femoral popliteal artery occlusive diseases.
作者
曹明昆
尹玉霞
卢天恒
侯文博
邹英华
张海军
CAO Mingkun;YIN Yuxia;LU Tianheng;HOU Wenbo;ZOU Yinghua;ZHANG Haijun(National United Engineering Laboratory for Biomedical Material Modification, Dezhou 251100, China;School of Materials Science and Engineering, University of Science and Technology Beijing,Beijing 100083, China;Department of Intervention & Vascular Surgery, Peking University First Hospital, Beijing 100034, China;Institute of International & Vascular Surgery, Tenth People's Hospital of Tongji University, Shanghai 200072, China)
出处
《中国介入影像与治疗学》
北大核心
2021年第3期142-147,共6页
Chinese Journal of Interventional Imaging and Therapy
关键词
外周动脉疾病
下肢
股动脉
腘动脉
闭塞性动脉硬化
球囊
荟萃分析
peripheral arterial disease
lower extremity
femoral artery
popliteal artery
arteriosclerosis obliterans
balloon
meta-analysis
