摘要
目的探讨血浆同型半胱氨酸(homocysteine,Hcy)水平与男性酒依赖患者复饮行为的相关性。方法随访住院治疗的234例男性酒依赖患者,根据患者出院3个月时酒精复饮情况分为复饮组(135例)和未复饮组(99例)。从电子病历系统采集患者的一般情况、饮酒史,以及入院时(即治疗前)血浆Hcy水平等资料。结果复饮组患者治疗前血浆Hcy浓度高于未复饮组患者[27.2(22.3,39.2)μmol/L vs.21.7(15.5,24.8)μmol/L,P<0.001]。logistic回归分析显示,Hcy是复饮的危险因素(OR=2.919,P=0.010)。受试者工作特征曲线分析示,Hcy的曲线下面积为0.688(95%CI:0.623~0.753),Hcy的最佳临界值为21.83μmol/L,此时灵敏度0.793,特异度0.515。结论高血浆Hcy水平与男性酒依赖患者戒断治疗后的复饮有关。
Objective To explore the correlation between plasma homocysteine(Hcy)levels and re-drinking behavior in male alcohol dependent patients.Methods Follow-up of 234 male alcohol-dependent patients who were hospitalized for treatment were divided into re-drinking group(135 cases)and non-re-drinking group(99 cases)according to their alcohol re-drinking status 3 months after discharge.The data was collected from the electronic medical record system including general condition of the patient,drinking history,and plasma Hcy level at the time of admission.Results The plasma Hcy concentration was higher in the re-drinking group than in the non-re-drinking group[27.2(22.3,39.2)μmol/L vs.21.7(15.5,24.8)μmol/L,P<0.001].Logistic regression analysis showed that Hcy was a risk factor for re-drinking(OR=2.919,P=0.010).The results of receiver operating characteristic curve analysis showed that the area under the curve of Hcy was 0.688(95%CI:0.623~0.753).The optimal cut-off value of Hcy was 21.83μmol/L.At this time,the sensitivity was 0.793 and the specificity was 0.515.Conclusion High plasma Hcy levels are related to re-drinking after withdrawal treatment in male alcohol dependent patients.
作者
徐琳
于鲁璐
王岚
宋美
王冉
高媛媛
王学义
XU Lin;YU Lulu;WANG Lan;SONG Mei;WANG Ran;GAO Yuanyuan;WANG Xueyi(The First Hospital of Hebei Medical University,Shijiazhuang 050031,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2020年第12期725-729,共5页
Chinese Journal of Nervous and Mental Diseases
基金
河北省重大医学科研课题(编号:zd2013085)
河北省卫健委医学科学研究课题(编号:20200119)
河北省引进国外智力项目(编号:YZ201801)。
关键词
酒依赖
同型半胱氨酸
复饮
Alcohol dependence
Homocysteine
Relapse
