摘要
目的:探讨甲基强的松龙联合丙种球蛋白治疗小儿特发性血小板减少性紫癜(ITP)的临床效果。方法:选取本院收治的84例ITP患儿,病例收治时间为2018年7月-2020年7月,按照抽签分组法将患儿分入到对照组与观察组中,各42例。对照组在常规治疗的基础上应用甲基强的松龙治疗,观察组在对照组基础上联合丙种球蛋白治疗。比较两组患儿的治疗疗效、指标复常时间及药物不良反应。结果:观察组治疗总有效率为90.48%(38/42),对照组为71.43%(30/42),对比差异有统计学意义(P<0.05)。观察组患儿出血控制时间、血小板复常时间、血小板上升时间均早于对照组,差异有统计学意义(P<0.05)。两组患儿皮疹、恶心呕吐、发热等不良反应总发生率对比差异无统计学意义(P>0.05)。结论:应用甲基强的松龙联合丙种球蛋白治疗ITP的效果值得信赖,能及早控制患儿的出血症状,提升血小板水平,促进患儿康复,且联合用药的安全性较好,具有较高的应用价值。
Objective:To investigate the clinical efficacy of Methylprednisolone combined with Gamma Globulin in the treatment of children with idiopathic thrombocytopenic purpura(ITP).Method:A total of 84 cases of ITP children admitted to our hospital from July 2018 to July 2020 were selected and divided into the control group and the observation group by lottery,42 cases in each group.The control group was treated with Methylprednisolone on the basis of conventional treatment,and the observation group was treated with Gamma Globulin on the basis of the control group.The therapeutic effect,index normalization time and adverse drug reactions were compared between the two groups.Result:The total effective rate of the observation group was 90.48%(38/42),and that of the control group was 71.43%(30/42),with significant difference(P<0.05).The bleeding control time,platelet normalization time and platelet rising time in the observation group were earlier than those in the control group(P<0.05).There was no significant difference in the total incidence of rash,nausea and vomiting,fever and other adverse reactions between the two groups(P>0.05).Conclusion:The curative effect of Methylprednisolone combined with Gamma Globulin in the treatment of ITP is reliable,which can control the bleeding symptoms of children as soon as possible,improve the platelet level,and promote the recovery of children,and the safety of combined medication is good,with high application value.
作者
陈珊莉
CHEN Shanli(Quanzhou Children's Hospital,Quanzhou 362000,China)
出处
《中外医学研究》
2021年第8期143-145,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
