摘要
目的探讨2型糖尿病患者幽门螺杆菌(Hp)根除后复发的相关因素。方法选取2018年1月~2019年4月于江西省上饶市广信区人民医院就诊的132例经13C尿素呼气试验证实Hp阳性的2型糖尿病患者作为研究对象,均经标准四联方案根除Hp治疗结束后4周复查13C尿素呼气试验阴性,所有入选的患者填写调查问卷,分别于停药6、12个月复查13C尿素呼气试验,比较复查Hp阳性与Hp阴性患者的基本资料。结果132例患者停药6个月的Hp复发率为10.61%(14/132);停药12个月时,因患者拒绝随访,脱落4例,Hp复发率13.16%(15/114)。Hp复发患者的病程、家庭其他人感染率、HbA1c水平高于Hp未复发患者,差异有统计学意义(P<0.05)。Logistic多因素回归分析显示,病程长(β=0.487,OR=1.627,95%CI=1.453~1.823)及家庭中其他人感染(β=1.088,OR=0.330,95%CI=0.161~0.673)是2型糖尿病患者Hp复发的危险因素(P<0.05)。结论病程长及家庭中其他人感染是导致2型糖尿病患者Hp根除后复发的危险因素,建议对于病程较长的2型糖尿病患者,家庭成员应共同检测并根除Hp。
Objective To investigate the related factors of helicobacter pylori(HP)recurrence after eradication in patients with type 2 diabetic(T2DM).Methods A total of 132 patients with type 2 diabetes who were confirmed to be Hp positive by 13C urea breath test in Guangxin People′s Hospital of Shangrao City,Jiangxi Province from January 2018 to April 2019 were selected as the research subjects.All patients were negative on 13C urea breath test 4 weeks after Hp eradication with standard quadruple regimen and completed the questionnaires.13C urea breath test was performed at 6 months and 12 months.The basic data of Hp positive and Hp negative patients were compared.Results The recurrence rate of HP in 132 patients was 10.61%(14/132)after 6 months of withdrawal.After 12 months of withdrawal,4 patients lost their HP due to their refusal to follow up,and the recurrence rate of HP was 13.16%(15/114).The course of disease,infection rate of other family members and HbA1c level of patients with recurrent HP were higher than those without recurrent HP,and the differences were statistically significant(P<0.05).Logistic multivariate regression analysis showed that long course of disease(β=0.487,OR=1.627,95%CI=1.453-1.823)and infection of other people in the family(β=1.088,OR=0.330,95%CI=0.161-0.673)were risk factors for Hp recurrence in T2DM patients(P<0.05).Conclusion The long course of disease and the infection of others in the family are the risk factors for the recurrence of Hp after eradication in type 2 diabetic patients.It is recommended that for patients with T2DM with a long course of disease,family members should jointly test for and eradicate HP.
作者
朱琳
范淑玲
王真
胡珊
ZHU Lin;FAN Shu-ling;WANG Zhen;HU Shan(Department of Internal Medicine,Jiangxi Medical College,Jiangxi Province,Shangrao334000,China;Department of General Internal Medicine,First Affiliated Hospital of Jiangxi Medical College,Jiangxi Province,Shangrao334000,China;Department of Anatomy and Embryo Group,Jiangxi Medical College,Jiangxi Province,Shangrao334000,China;Department of Emergency,Guangxin People′s Hospital of Shangrao City,Jiangxi Province,Shangrao334000,China;Department of Surgery,Jiangxi Medical College,Jiangxi Province,Shangrao334000,China;Department of Dermatology,First Affiliated Hospital of Jiangxi Medical College,Jiangxi Province,Shangrao334000,China)
出处
《中国当代医药》
CAS
2021年第9期135-138,共4页
China Modern Medicine
基金
江西省教育厅科学技术研究项目(161324)。
