摘要
冠状动脉粥样硬化性心脏病(CHD)是多基因遗传和环境等因素相互作用的复杂性疾病,血瘀证是其常见证型之一。随着DNA甲基化/羟甲基化逐渐成为表观遗传学研究的新热点,探讨DNA甲基化/羟甲基化与CHD之间的研究逐渐增多。文章将根据早发冠心病血瘀证与遗传易感基因、DNA甲基化/羟甲基化状态和mRNA差异表达间的相关性研究,探索其对早发冠心病血瘀证发生发展的影响,为早发冠心病血瘀证临床诊治提供参考,亦为中医证候本质研究提供新的突破点和思路。
Coronary heart disease is a complex disease caused by multiple genetic inheritance and environmental factors, and blood stasis syndrome is one of the common syndromes. As DNA methylation/hydroxymethylation has gradually become a new hotspot in epigenetics, the researches on the relationship between DNA methylation/hydroxymethylation and coronary heart disease are increasing. Based on the correlation between premature coronary heart disease with blood stasis syndrome and genetic susceptibility genes, DNA methylation/hydroxymethylation status and mRNA differential expression, this paper explored its influence on the occurrence and development of premature coronary heart disease with blood stasis syndrome, to provide references for clinical diagnosis and treatment of premature coronary heart disease with blood stasis syndrome, and to provide new breakthrough points and ideas for the study of TCM syndrome essence as well.
作者
李杰
张书萌
张湘卓
江雨洁
陈伶利
LI Jie;ZHANG Shu-meng;ZHANG Xiang-zhuo;JIANG Yu-jie;CHEN Ling-li(Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第12期5945-5948,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81673963,No.81874375)
湖南省自然科学基金项目(No.2018JJ2298,No.2020JJ4464)
湖南省教育厅重点项目(No.17A163)
湖南中医药大学“十三五”一级学科基础医学建设项目(No.06)。
关键词
DNA甲基化
羟甲基化
MRNA表达
早发冠心病
血瘀证
DNA methylation
Hydroxymethylation
mRNA expression
Premature coronary heart disease
Syndrome of blood stasis
