摘要
对济宁市１００例冠心病病人进行了１：１配比的病例－对照研究，详细分析了影响冠心病发病的环境因素和遗传因素。条件ｌｏｇｉｓｔｉｃ回归分析结果表明，高脂饮食习惯、高血压病史、冠心病家族史、体重指数是冠心病的主要危险因素；多食根茎类蔬菜是冠心病的保护因素。冠心病人亲属的发病比一般人群具有更高的患冠心病危险性，按Ｆａｌｃｏｎｅｒ公式计算的先证者一、二、三级亲属的加权平均遗传度为５２．４３±４．７１％，分离分析表明冠心病不符合常染色体显性或隐性遗传的方式，而较符合多基因遗传。
A 1 :
1 case control study was performed in 100 cases of coronary heart disease (CHD)and 100
matched controls se-lected from the hospitals in Jiningl.The environmental and ge-metic factors
of CHD were studied by conditioneal logistic re-gression analysis.The results showed that high
fat diet ,case history of hypertension,family history of CHD and body weight index were the
major risk factors of CHD,while the consumption of rhizome vegetables was the protective
factor.The risk of involoing CHD in the person with CHD familyhistory was higher than those
without such hustory.Accord-ing to Falconer formula,the weighted mean heritability of CHD was
52.3±4.71%. The results demonstrated that environmental factor and genetic factor played an
important role in the pathogenesis of CHD.
出处
《中国慢性病预防与控制》
CAS
1995年第5期196-198,213,共4页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
冠心病
病因
危险因素
遗传因素
Coronary heart disease Environmental
fac-tor Caseocontrol study Heritability Segregation analysis
