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免疫组化SP法检测人乳腺癌组织中VEGF和VEGF-C的表达及意义

Immunohistochemical SP Method for Detecting the Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor-C in Human Breast Cancer and Its Significance
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摘要 目的研究免疫组化SP法检测人乳腺癌组织中VEGF和VEGF-C的表达情况及检测意义。方法选取2018年5月至2019年5月营口市中心医院收治的150例人乳腺癌患者和50例良性乳腺纤维腺瘤患者,对两组患者的临床资料进行回顾性对比分析,采用免疫组化SP法检测,以病理检查结果为金标准,分析VEGF、VEGF-C表达情况以及该指标与患者临床病理因素的相关性。结果乳腺癌组VEGF、VEGF-C阳性表达率与患者的肿瘤分期、淋巴结转移情况的相关性均比良性乳腺纤维腺瘤组明显(P<0.05)。结论乳腺癌患者的VEGF、VEGF-C的表达情况与乳腺癌的发生、转移具有直接关系,免疫组化SP法检测能够有效提高乳腺癌患者的VEGF、VEGF-C的阳性检出率。 Objective To study the expression of vascular endothelial growth factor(VEGF)and vascular endothelial growth factor-C(VEGF-C)in human breast cancer tissues by immunohistochemical SP method and analyze its significance.Methods Select 150 human breast cancer patients and 50 benign breast fibroadenoma patients who were admitted to Yingkou Central Hospital in May 2018 and May 2019.The clinical data of the two groups of patients were retrospectively compared and analyzed,and the immunohistochemical SP method was used.Detection,with pathological examination results as the gold standard,analyze the expression of VEGF and VEGF-C and the correlation between this index and the clinical pathological factors of the patient.Results The positive expression rates of VEGF and VEGF-C in the experimental group were significantly higher than those in the control group in terms of tumor stage and lymph node metastasis(P<0.05).Conclusion The expression of vascular endothelial growth factor and vascular endothelial growth factor-C in patients with breast cancer is directly related to the occurrence and metastasis of breast cancer.Immunohistochemical SP method can effectively improve the positive detection rate of vascular endothelial growth factor and vascular endothelial growth factor-C in patients with breast cancer.
作者 刘丽 白春侠 曹美荣 LIU Li;BAI Chunxia;CAO Meirong(Yingkou Central Hospital,Yingkou 115000,China)
机构地区 营口市中心医院
出处 《中国医药指南》 2021年第9期118-119,共2页 Guide of China Medicine
关键词 乳腺癌 免疫组化 SP法检测 血管内皮生长因子 病理检查 Breast cancer Immunohistochemistry SP detection Vascular endothelial growth factor Pathological examination
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