摘要
目的:通过HPLC法,对乌兹别克斯坦、内蒙古共14批甘草中的甘草苷、甘草酸有效成分含量进行测定,并作出质量一致性评价。方法:按照2015版《中国药典》中甘草的有效成分含量检测方法,将甘草中甘草酸和甘草苷的含量作为检测指标,评价14批不同来源中甘草的质量。结果:包头3号、包头5号、内蒙古家种甲级、内蒙古家种丙级、内蒙古家种丁级、乌兹别克斯坦野生1号及乌兹别克斯坦野生2号药材甘草苷含量未达到药典标准(甘草苷含量>0.5%),包头家种2号、内蒙古浮草、、内蒙古家种甲级、内蒙古家种丙级、内蒙古家种丁级甘草酸含量均达到药典标准(甘草酸含量>2.0%),其余样品均符合2015版药典标准。结论:国外及内蒙古各批次甘草中甘草苷、甘草酸铵的含量存在较大差异,以内蒙古包头家种1号样品最佳。
Objective: To determine the content of glycyrrhizin and glycyrrhizic acid in 14 batches of licorice in Uzbekistan and Inner Mongolia by HPLC, and evaluate the quality consistency. Methods:According to the detection method of licorice in the 2015 edition of "Chinese Pharmacopoeia", the content of glycyrrhizic acid and glycyrrhizin in licorice were used as the detection indicators to evaluate the quality of licorice in 14 batches of different sources. Results:Baotou No. 3,Baotou No. 5, Inner Mongolia family species A, Inner Mongolia family species C, Inner Mongolia family species D, Uzbekistan Wild No. 1 and Uzbekistan Wild No. 2 medicinal materials glycyrrhizin content did not meet the pharmacopoeial standard(glycyrrhizin content >0.5%), the glycyrrhizic acid content of Baotou Jiachong No. 2, Inner Mongolia Floating Grass, Inner Mongolia Jiazhong A, Inner Mongolia Jia Chong, and Inner Mongolia Jia Chong D grade all reached the pharmacopoeia standard(glycyrrhizic acid content> 2.0%) All comply with the 2015 pharmacopoeia standards. Conclusion :The contents of glycyrrhizin and ammonium glycyrrhizinate in different batches of licorice in foreign countries and Inner Mongolia are quite different, and the sample from Baotou Jiazhong No. 1 in Inner Mongolia is the best.
作者
张男
包保全
韩东宁
康敏
张屏
ZHANG Nan;BAO Bao-quan;Han Dong-ning(College of Pharmacy,Inner Mongolia Medical University,Hohhot 010059 China)
出处
《疾病监测与控制》
2021年第1期1-6,17,共7页
Journal of Diseases Monitor and Control
关键词
HPLC法
甘草
甘草苷
甘草酸铵
质量分析
HPLC method
licorice
glycyrrhizin
ammonium glycyrrhizinate
quality analysis
