摘要
Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impairment(MCI).Methods:This study is a randomized controlled clinical trial conducted in the Memory Center of Fujian Provincial hospital.Thirty-six MCI patients were randomly distributed into two groups.One group underwent a 16-week creative expression program(CrExp,n=18)and the other performed as a control group(CG,n=18)by general social activities.The amplitude and latency of ERP-P300 from the central(Cz),parietal(Pz),frontal(Fz)cortices and task reaction time(RT)were assessed at baseline,postinterventi on,and 24-week follow-up.Results:The CrExp group showed greater differences than CG of P300 latency in Cz(F=4.37,P=0.015),Pz(F=2.78,P=0.009),Fz(F=6.45,P=0.031)brain area after 16 weeks of intervention and in Fz(F=3.23,P=0.028),Cz(F=3.79,P=0.024),and Pz(F=5.60,P=0.036)at 24 weeks follow-up.Also,we analyzed the task reaction time between two groups and found that a shorten reaction time at postintervention(F=4.47,P=0.011)and 24 weeks follow-up(F=3.12,P=0.007)in the CrExp group.However,there was no difference in P300 amplitude in either brain area between the two groups.Conclusion:The electrophysiological results of the creative expression cognitive therapy group were more obvious than those of the general cognitive therapy group,and the latency and task reaction time may be considered as supported parameters in diagnosing the effects during non-drug therapy intervention in clinical practice.
目的本研究旨在评估16周的创作性表达活动对轻度认知障碍患者事件相关电位及任务反应时间的影响。方法本研究是一项随机对照临床试验。选取福建省医院记忆中心36例轻度认知障碍(mild cognitive impairment,MCI)患者(干预组18例,对照组18例)为研究对象。对干预组患者实施为期16周的创作性表达活动(creative expression program,CrExp),对照组进行一般社交活动。在干预前、干预16周和24周后,采用肌电图/诱发电位仪测量患者中央中线(Cz)、顶中线(Pz)及额中线(Fz)脑区的事件相关电位(P300)波幅、潜伏期和任务反应时间并进行数据比较。结果干预16周后,干预组患者Cz(F=4.37,P=0.015)、Pz(F=2.78,P=0.009)、Fz(F=6.45,P=0.031)脑区P300潜伏期及24周随访时Fz(F=3.23,P=0.028)、Cz(F=3.79,P=0.024)、Pz(F=5.60,P=0.036)脑区P300潜伏期均大于对照组。此外,干预组患者在干预16周后(F=4.47,P=0.011)和24周随访时(F=3.12,P=0.007)反应时间较对照组患者缩短。然而,两组患者不同脑区的P300波幅比较,差异无统计学意义(P>0.05)。结论创作性表达活动组患者的电生理结果较一般社交活动组更明显,可将潜伏期和任务反应时间作为临床非药物干预中诊断效果的参考依据。
作者
Junyu Zhao
Hong Li
Rong Lin
Minzhi Xie
Yinzhou Wang
Huiying Chen
赵珺瑜;李红;林榕;谢忞之;汪银洲;陈惠英(School of Nursing,Fujian Medical University,Fuzhou,China;Department of Nursing,Fujian Provincial Hospital,Fuzhou,China;Department of Neurology,Fujian Provincial Hospital,Fuzhou,China;Center of Patients Admission and Discharge Service,Fujian Provincial Hospital,Fuzhou,China)
基金
supported by the Youth research project of Fujian Provincial Health Commission(No.2018-1-75)
Joint Fund of Fujian Province Scientific and Technological Department(No.2018Y9102)
Soft Science Project of Fujian Science and Technology Department(No.2019R0055)
National Science Foundation of China(No.81571379).
