摘要
目的对某院成人呼吸道感染病例进行病原学及流行病学分析,为呼吸道感染性疾病的临床诊治和感染防控提供病原学依据。方法收集2015年1月至2019年12月在北京市健宫医院就诊的1168例成人呼吸道感染病例的呼吸道标本,采用多重实时荧光定量PCR检测方法对多种呼吸道病原体进行检测,对检出病原体的病原学分布及流行病学特征进行统计分析。结果1168例患者的标本中检出335例阳性,标本阳性检出率为28.68%(335/1168)。所有阳性病原体检出前三位依次为甲型流感病毒、肺炎支原体和副流感病毒、鼻病毒。18~59岁成人组以甲型流感病毒和肺炎支原体占优势,≥60岁老年组以甲型流感病毒、副流感病毒、鼻病毒为主。上呼吸道感染病例检出病原体主要为甲型流感病毒、乙型流感病毒和副流感病毒;肺炎病例检出病原体以甲型流感病毒、肺炎支原体为主。冬春季的检出阳性率明显高于夏秋季,冬春季以甲型流感病毒、乙型流感病毒为主,夏秋季以肺炎支原体、鼻病毒为主。结论该院近五年来呼吸道感染病原体以甲型流感病毒、肺炎支原体和副流感病毒、鼻病毒为主。临床医生应关注病毒性肺炎及支原体肺炎的感染,及时进行诊断及治疗。
Objective To analyze the etiology and epidemiology of adult respiratory tract infection cases in Beijing Jian'gong Hospital,so as to provide etiological basis for clinical diagnosis and treatment of respiratory tract infectious diseases and infection prevention and control.Methods 1168 respiratory tract specimens of adults with respiratory tract infection admitted to Beijing Jian'gong Hospital from January 2015 to December 2019 were collected,the multiple real-time fluorescence quantitative PCR detection methods were used to detect various respiratory pathogens,and the pathogenic distribution and epidemiological features of the detected pathogens were statistically analyzed.Results Of the 1168 specimens,335 were positive,and the positive rate was 28.68%(335/1168).The top three positive pathogens were influenza A virus,mycoplasma pneumoniae,parainfluenza virus and rhinovirus.The adults aged 18-59 years were dominated by influenza A virus and mycoplasma pneumoniae,while those aged≥60 years were dominated by influenza A virus,parainfluenza virus and rhinovirus.The main pathogens detected in upper respiratory tract infection cases were influenza A virus,influenza B virus and parainfluenza virus.The pathogens detected in pneumonia cases were influenza A virus and mycoplasma pneumoniae.The positive rate of detection in winter and spring was significantly higher than that in summer and autumn.Influenza A and B viruses were the main types in winter and spring,and mycoplasma pneumoniae and rhinovirus were the main pathogens in summer and autumn.Conclusion In recent five years,influenza A virus,mycoplasma pneumoniae,parainfluenza virus and rhinovirus are the main pathogens of respiratory tract infection in our hospital.Clinicians should pay attention to the infection of viral pneumonia and mycoplasma pneumonia and make timely diagnosis and treatment.
作者
刘薇
秦迪
初艳慧
黄芳
LIU Wei;QIN Di;CHU Yanhui;HUANG Fang(Department of Infectious Disease,Beijing Jian'gong Hospital,Beijing 100054,China;Department of Infectious Disease Prevention and Control,Beijing Xicheng District Center for Diseases Prevention and Control,Beijing 100120,China;Institute of Immunization Prevention,Beijing Center for Diseases Prevention and Control,Beijing 100013,China)
出处
《中国医药科学》
2021年第4期13-16,共4页
China Medicine And Pharmacy
基金
“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项课题(2017ZX10103004)。
关键词
呼吸道感染
病原学
呼吸道病原体
病毒
Respiratory tract infection
Etiology
Respiratory tract pathog ens
Virus
