摘要
获得性免疫缺陷综合征(AIDS),即艾滋病的治疗是一个漫长的过程。3种及以上的抗逆转录病毒药物的联合使用显著提高病毒学疗效,但同时也增加AIDS患者发生潜在药物相互作用(DDI)的风险,尤其当患者合并机会性感染,用药更加复杂多样时风险增加。了解药物的代谢途径及转运方式可以更好地预判DDI的发生并相应调整治疗方案以减少对患者产生不良影响的风险。本文总结了AIDS治疗药物间的相互作用以及AIDS治疗药物与合并机会性感染和其他常见疾病治疗药物的DDI,为提升用药安全提供参考。
Acquired immunodeficiency syndrome(AIDS)treatment is a long process. The combination of three or more antiretroviral drugs significantly improves the virological efficacy,but it also increases the risk of potential drug interactions in human immunodeficiency virus(HIV)infection/AIDS patients,especially when patients have occasional infections,medications are more complex and diverse. Understanding the metabolic pathways and transport modes of drugs enables us to better predict the occurrence of drug-drug interaction(DDI)and make corresponding adjustments to reduce the adverse effects on patients. This article summarizes the interactions of anti-AIDS drugs and their interactions with drugs for treating occasional infections and other common diseases in order to provide a reference for improving medication safety.
作者
曹雅睿
杜小莉
CAO Ya-rui;DU Xiao-li(Department of Pharmacy,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)
出处
《临床药物治疗杂志》
2021年第3期14-19,共6页
Clinical Medication Journal
