摘要
骨质疏松症是一种由成骨细胞和破骨细胞活性失衡引发的骨量减少的疾病,是肝硬化、胆汁淤积性肝病、肝移植患者常见的并发症。过去几十年里关于免疫细胞激活、慢性炎症、肠道微生物等许多研究进展提高了对肝硬化继发性骨质疏松症的认识。现对肝硬化继发性骨质疏松症的流行病学、发病机制及诊治进展进行综述。
Osteoporosis is a bone loss disease caused by the imbalance of osteoblast and osteoclast.It is a common complication of patients with liver cirrhosis,cholestatic liver disease,and liver transplantation.Over the past few decades,many researchs have raised the awareness of immune cell activation,chronic inflammation,intestinal microflora,etc.in liver cirrhosis and secondary osteoporosis.This article reviews the progress of the epidemiology,pathogenesis,diagnosis and treatment of liver cirrhosis and secondaiy osteoporosis.
作者
杨丽
杨长青
Yang Li;Yang Changqing(Division of Gastroenterology and Hepatology,Digestive Disease Institute,Shanghai Tongji Hospital,Tongji University School of Medicine,Shanghai 200065,China)
出处
《中华肝脏病杂志》
CSCD
北大核心
2021年第3期204-208,共5页
Chinese Journal of Hepatology
基金
国家自然科学基金(81670571,81820108006)
上海市临床重点专科建设项目(SHSLCZDZK06801)
上海申康三年行动计划重大临床研究项目(SHDC2020CR2030B)。
关键词
肝硬化
继发性骨质疏松症
骨密度
慢性炎症
肠道菌群
Liver cirrhosis
Secondary osteoporosis
Bone mineral density
Chronic inflammation
Gut microbiota
