摘要
以三甲基氯硅烷、乙酰胺为原料,三乙胺为缚酸剂,选用2,6-二甲基苯胺为主催化剂、咪唑为辅助催化剂,双催化合成医药中间体N,O-双(三甲基硅基)乙酰胺。通过优化反应条件,实现一种N,O-双(三甲基硅基)乙酰胺双催化的绿色合成方法。
Using trimethylchlorosilane and acetamide as the raw material,triethylamine as the acid binding agent,2,6-dimethylaniline as the main catalyst and imidazole as the auxiliary catalyst,the pharmaceutical intermediate N,O-bis(trimethylsilyl)acetamide was synthesized by a dual catalytic method.Then,a green synthesis method with N,O-bis(trimethylsilyl)acetamide dual catalysis is realized by optimizing the reaction conditions.
作者
褚俸廷
刘健
刘振亮
张恭孝
Chu Fengting;Liu Jian;Liu Zhenliang;Zhang Gongxiao(School of Chemistry and Pharmaceutical Engineerin,Shandong First Medical University,Taian 271016,China)
出处
《山东化工》
CAS
2021年第4期20-21,共2页
Shandong Chemical Industry
基金
2020年山东省大学生创新创业训练计划立项项目(项目编号:S202010439088)。
