摘要
肌腱损伤常需手术治疗,能够一定程度上恢复肌腱的结构与稳定性,但往往难以恢复到正常的强度,其主要原因是肌腱自然愈合能力有限,修复后的肌腱不能完全恢复功能。随着对肌腱愈合的研究不断加深,生物学技术为肌腱修复提供了新的方向。当前对肌腱修复的研究热点之一是使用生物辅助物来促进肌腱愈合,这些辅助物包括肌腱干/祖细胞(TSPCs)、生长因子等。笔者就TSPCs和生长因子促进肌腱愈合的作用机制研究进展作一综述,为肌腱损伤的生物学治疗和研究提供参考。
Tendon injuries often need surgical treatment,which enables to repair the structure and stability of the tendons to a certain extent,whereas it is difficult to restore to their normal strength.The primary reason is that the natural healing ability of tendons is limited and the functions of the repaired tendons cannot be restored completely.As further researches on tendon healing are conducted,biological technology provides a novel orientation for tendon repair.One of the research hotspots of tendon repair currently is to facilitate tendon healing using biological auxiliaries,including tendon stem 1 progenitor cells(TSPCs)and growth factors.The authors review the research progress in mechanism of TSPCs and growth factors accelerating tendon healing in order to provide a reference for the biological treatment of tendon injuries.
作者
赵海波
王天瑞
李天予
申友亮
于腾波
张英泽
Zhao Haibo;Wang Tianrui;Li Tianyu;Shen Youliang;Yu Tengbo;Zhang Yingze(Medical College of Qingdao University,Qingdao 266000,China;Department of Orthopedics,Affiliated Hospital of Qingdao University,Qingdao 266000,China;Trauma Emergency Center,Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2021年第3期284-288,共5页
Chinese Journal of Trauma
基金
国家自然科学基金(31872310)。
