摘要
背景:成纤维生长因子2作为腱-骨愈合和软骨修复过程中重要的生长因子,对加速腱-骨愈合和软骨修复有积极的促进作用。目的:综述成纤维生长因子2在腱-骨愈合及软骨修复方面的应用及目前面临的问题。方法:计算机检索CNKI数据库、Pub Med数据库以及Elsevier数据库,中文检索词为:"成纤维生长因子,肌腱,骨,软骨,修复,组织工程"。英文检索词为:"fibroblast growth factor 2,tendon,bone,cartilage,repair,tissue engineering"。检索2000年1月至2018年3月收录的有关成纤维生长因子2在腱-骨愈合和软骨修复方面的文章。通过阅读文题和摘要进行初步筛选,排除与文章主题不相关的文献,最终纳入64篇文献进行结果分析。结果与结论:(1)成纤维生长因子2在腱-骨愈合过程中有重要的作用,能够加速腱-骨愈合。其主要是通过诱导转化生长因子和骨形态发生蛋白基因的表达,促进骨髓间充质干细胞增殖和Ⅰ型胶原、Ⅲ型胶原的含量;(2)成纤维生长因子2对软骨损伤修复也有明显的促进作用,通过激活FGF/FGFR2等通路促进骨髓间充质干细胞的增殖,调节其SOX9的表达,促进其向软骨分化。作用于软骨下骨,上调软骨下骨中骨形态发生蛋白2和4等内源性生长因子的表达,从而促进软骨的形成;(3)但是,当前关于对成纤维生长因子2的研究还处于基础实验阶段,尚缺乏大量临床试验的证据。
BACKGROUND： As an important growth factor in tendon-bone healing and cartilage repair, fibroblast growth factor 2（FGF-2） has a positive effect on accelerating tendon-bone healing and cartilage repair.OBJECTIVE： To review the application and the current problems of FGF-2 in tendon-bone healing and cartilage repair. METHODS： A computer-based search of CNKI, Pub Med, and Elsevier databases was performed for retrieving articles concerning the application of FGF-2 in tendon-bone healing and cartilage repair published from January 2000 to March 2018. The keywords were ＂fibroblast growth factor 2, tendon, bone, cartilage, repair, tissue engineering＂ in English and Chinese, respectively. Finally 64 eligible articles were enrolled for result analysis after excluding irrelative articles by reading the titles and abstracts. RESULTS AND CONCLUSION： FGF-2 plays an important role in tendon-bone healing process and can accelerate tendon-bone healing by increasing the expression levels of transforming growth factor and bone morphogenetic protein, promoting the proliferation of bone marrow mesenchymal stem cells and increasing the contents of collagen type I and III. Moreover, FGF-2 can promote the repair of cartilage injury by activating FGF/FGFR2 and other signaling pathways to promote the proliferation of bone marrow mesenchymal stem cells, regulate the expression of sox9 and promote the differentiation of bone marrow mesenchymal stem cells into chondrocytes. Besides, it promotes the formation of cartilage by up-regulating the expression levels of endogenous growth factors such as bone morphogenetic protein 2 and 4 in subchondral bone. However, the studies on FGF-2 are in the pre-clinical stage, so more clinical researches are required.
作者
张骏
杨继滨
尤奇
李豫皖
朱喜忠
熊华章
金瑛
彭旭
葛振
刘毅
Zhang Jun;Yang Ji-bin;You Qi;Li Yu-wan;Zhu Xi-zhong;Xiong Hua-zhang;Jin Ying;Peng Xu;Ge Zhen;Liu Yi(First Department of Orthopedics,Zunyi Medical University,Zunyi 563000,Guizhou Province,Chin)
出处
《中国组织工程研究》
CAS
北大核心
2018年第20期3243-3249,共7页
Chinese Journal of Tissue Engineering Research
基金
贵州省科学技术基金资助项目(黔科合LH字[2016]7477号)~~
