摘要
砷是一种在低剂量长期暴露下可诱导癌症发生,而在高剂量短时间干预下可用于治疗癌症的环境类金属物,其对机体各器官和系统产生的不可逆损害深受人们关注。目前除氧化应激、细胞凋亡及DNA甲基化外,非编码RNA中的微小RNA(miRNA)作为不改变基础DNA序列但可调节基因活动变化的明星分子,已成为当前砷毒性机制研究的热点。miRNA的异常表达与砷毒物引起的机体多脏器损伤、生殖毒性和细胞恶性转化等密切相关。本文对近年有关miRNA在环境砷诱导机体毒性损伤方面做一综述,以期为砷所致疾病的诊断和治疗提供新思路。
Arsenic is an environmental metallic substance that can induce cancer at low dose and long-term exposure,but can treat cancer too with high dose and short-term intervention,its irreversible damage effect to various organs and systems has also received much attention.In addition to oxidative stress,apoptosis and DNA methylation,the role of microRNAs(miRNA),in non-coding RNA as a star molecule that do not change the basic DNA sequence but can regulate changes of gene activity has already become a new focus in arsenic toxicity research.In recent years,a large number of studies have shown that the abnormal expression of miRNA was closely related to multiple organ damage,reproductive toxicity,and cell malignant transformation of the body caused by arsenic.This article will give a brief review on environmental arsenic-induced toxic damage on organisms,thereby provide some new ideas for the diagnosis and treatment of arsenic-induced diseases.
作者
屈腾佼
孙艺菲
刘帼芬
谷仕艳
何作顺
QU Teng-jiao;SUN Yi-fei;LIU Guo-fen;GU Shi-yan;HE Zuo-shun(School of Public Healthy of Dali University,Dali 671000,China)
出处
《中国工业医学杂志》
CAS
2020年第6期512-515,共4页
Chinese Journal of Industrial Medicine
基金
2020年度云南省教育厅科学研究基金项目(2020Y0525)
N6-甲基腺苷参与Ⅱ型糖尿病的作用及机制研究(202001AU070015)。
