摘要
诱导氧化应激是镉致肾损伤的主要机制,而m^6A可参与氧化应激的发生发展,这为从RNA甲基化角度研究镉诱导氧化应激提供一种新思路。本文通过对最近几年的有关文献进行研究,综述镉致肾损伤以及N6-甲基腺苷(N^6-methyladenosine,m^6A)与氧化应激之间的关联性,为阐明镉毒性分子机制提供理论依据。收集国内外文献,并进行整理、总结和分析。深入研究镉毒性、氧化应激和RNA甲基化三者之间的调控关系,阐明镉致肾损伤的分子机制,可为镉毒性的预防和治疗提供科学依据。
By teasing out the recent years of relevant literature research, the paper summarizes the association between cadmiuminduced renal injury and N6-methyladenosine(m^6A) and oxidative stress, to provide theoretical basis for elucidating the molecular mechanism of cadmium toxicity. The authors Collect domestic and foreign literature, and collate, summarized and analyzed the literature. Many studies have shown that oxidative stress is the main mechanism of renal injury induced by cadmium, and m6 A is involved in the occurrence and development of oxidative stress, which provides a new way to study cadmium-induced oxidative stress from the perspective of RNA methylation. To further study the regulatory relationship among cadmium toxicity, oxidative stress and RNA methylation, and to elucidate the molecular mechanism of cadmium induced kidney injury can provide scientific basis for prevention and treatment of cadmium toxicity.
作者
李萌竹
谷仕艳
何作顺
LI Meng-zhu;GU Shi-yrm;HE Zuo-shun(School of Public Health,Dali University,Dali Yunnan,671000,China)
出处
《职业与健康》
CAS
2019年第15期2141-2144,共4页
Occupation and Health
基金
中国西南药用昆虫及蛛形类资源开发利用协同创新中心2018年度开放课题(CIC1802)
大理大学博士科研启动项目(KYBS2018006)
关键词
N^6-甲基腺苷
氧化应激
镉
肾损伤
N^6-methyladenosine
Oxidative stress
Cadmium
Renal injury
