摘要
目的观察中风回春片对脑中风恢复期大鼠的治疗作用及机理研究。方法采用Zea-Longa法制备MCAO模型大鼠,将模型大鼠随机分为五组,分别为假手术组、模型组、中风回春片低、中、高剂量组(200 mg/kg、300 mg/kg、500 mg/kg),每组8只,灌胃给药4周,对各组大鼠的肢体功能、肌力功能和学习记忆功能进行检测;ELISA法测定各组大鼠血清中肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β),白介素-6(IL-6)的含量。结果与模型组相比,中风回春片对于改善MCAO模型大鼠的前肢抓力及学习记忆功能有显著作用(P<0.05),对大鼠血清中TNF-α、IL-1β,IL-6的水平有明显的抑制作用(P<0.05),且呈剂量依赖性。结论中风回春片对脑中风恢复期大鼠具有显著的治疗作用,可改善其运动功能及前肢抓力,抑制血清中炎性因子的释放。其作用机制可能是通过抑制炎症反应而对脑中风恢复期大鼠起效。
Objective To investigate the effect and mechanisms of Zhongfeng Hui chun Tablet in the convalesent period of stroke.Methods The MCAO model rats can be prepared by Zea-Longa method,The experimental rats were randomly divided into sham operation group,model group,Zhongfeng Huichun tablets groups(200 mg/kg、300 mg/kg、500 mg/kg)and the positive control group,8 rats in each group.The limbs function,muscle strength and function and the learning and memory function of rats were determined after intragastric administration for 4 weeks.The concentration of TNF-α,IL-1βand IL-6 in the serum of rats was measured by ELISA.Results Zhongfeng Huichun tablets can improved the limbs function,muscle strength and function and the learning and memory function of rats compared with the model group.The levels of TNF-α,IL-1βand IL-6 were significantly decreased in various Zhongfeng Huichun tablets groups.Conclusion Zhongfeng Huichun Tablets has a significant effect in the recovery period of stroke in rats.It can improve motor function and forelimb grip,and inhibit the release of inflammatory factors in rats.
作者
画奕惟
李想
苗鹏飞
HUA Yi-xiong;LI Xiang;MIAO Peng-fei(Hong Kong Baptist University,Hongkong 999077,China)
出处
《中国处方药》
2021年第3期38-40,共3页
Journal of China Prescription Drug
