摘要
目的基于厚朴"发汗"前后多指标质量差异关键属性优化厚朴"发汗"工艺。方法采用HPLC法同时测定"发汗"厚朴中紫丁香苷、木兰花碱、厚朴苷A、和厚朴酚及厚朴酚含量,采用CRITIC-层次分析法(CRITIC-AHP)复合加权法计算权重系数,多指标综合评分,结合Box-Behnken响应面法考察水煮时间、堆积天数、干燥温度及干燥时间对"发汗"厚朴质量的影响,优选厚朴"发汗"工艺。结果厚朴较佳发汗工艺为取厚朴药材,沸水水煮2min,堆积发汗1d,晾晒7 d后于45℃烘箱内干燥36 h。结论采用多指标含量测定、CRITIC-AHP复合加权法结合响应面法优厚朴"发汗"工艺,为厚朴产地加工"发汗"工艺考察提供参考。
Objective To optimize the"sweating"process in producing area for Magnoliae Officinalis Cortex(MOC)based on multi-index determinant attributes of quality difference caused by"sweating".Methods A comprehensive multi-index evaluation of the quality of MOC after"sweating"was made.The contents of syringoside,magnolflorine,magloside A,honokiol,and magnolol in"sweating"MOC were determined by HPLC,the weight coefficients were calculated by CRITIC-AHP composite weighting method.The effects of boiling time,stacking days,drying temperature and time on the quality were investigated by the method of Box-Behnken response surface,and then the optimization was selected.Results The optimal sweating process of MOC was as following:Boil MOC with boiling water for 2 min;Heap them for"sweating"for 1 d;Air-dry them for 7 d and then oven dry them in 45℃for 36 h.Conclusion This study has optimized the process of"sweating"process of MOC based on multi-index determination,CRITIC-AHP composite weight calculation and Box-Behnken response surface methodology,which provides the references for the"sweating"process in producing area of MOC.
作者
刘畅
王潇
刘芳
刘绍
胡慧玲
傅超美
邓彬
LIU Chang;WANG Xiao;LIU Fang;LIU Shao-yang;HU Hui-ling;FU Chao-mei;DENG Bin(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Chengdu Dior Pharmaceutical Group Co.,Ltd.,Chengdu 610000,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第3期677-684,共8页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金项目青年基金项目(81603300)
中国博士后科学基金面上项目“西部地区博士后人才资助计划”(2020M673569 XB)
四川省科技厅项目(2020YJ0370)
国家药品监督管理局中药材质量监测评价重点实验室开放课题(2020NMPA-CDDC03)。
