摘要
目的探讨血清胃蛋白酶原Ⅰ(pepsinogenⅠ,PGⅠ)、胃泌素-17(gastrin-17,GS-17)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)与幽门螺杆菌(Helicobacter pylori,HP)感染消化性溃疡(peptic ulcer,PU)的相关性。方法选取PU 132例,根据有无HP感染将其分为HP感染PU组(75例)和无HP感染PU组(57例)两组。HP感染PU组中胃溃疡29例,十二指肠溃疡46例;无HP感染PU组中胃溃疡30例,十二指肠溃疡27例。另选取同期进行体检的健康体检者47例作为健康体检组。比较3组血清PGⅠ、GS-17及TNF-α水平,HP感染PU组和无HP感染PU组不同溃疡类型患者血清PGⅠ、GS-17及TNF-α水平;采用Logistic回归分析探讨血清PGⅠ、GS-17及TNF-α水平与HP感染PU的关系;采用受试者工作特征(ROC)曲线分析血清PGⅠ、GS-17、TNF-α检测及三者联合检测对HP感染PU的诊断价值。结果HP感染PU组和无HP感染PU组血清PGⅠ、GS-17和TNF-α水平均高于健康体检组,HP感染PU组血清PGⅠ、GS-17和TNF-α水平高于无HP感染PU组,差异有统计学意义(P<0.01)。HP感染PU组胃溃疡患者血清GS-17水平低于十二指肠溃疡患者,差异有统计学意义(P<0.01)。HP感染PU组胃溃疡和十二指肠溃疡患者血清PGⅠ、GS-17和TNF-α水平均高于无HP感染PU组胃溃疡和十二指肠溃疡患者,差异有统计学意义(P<0.01)。Logistic回归分析结果显示,血清PGⅠ>70 U/ml、GS-17>55 pg/ml及TNF-α>10 ng/ml是HP感染PU的危险因素(P<0.01)。ROC曲线分析结果显示,血清PGⅠ、GS-17和TNF-α三者联合检测对HP感染PU的诊断价值最佳。结论血清PGⅠ、GS-17及TNF-α水平升高与HP感染PU有一定相关性,三者联合检测对HP感染PU的诊断价值最佳。
Objective To explore the correlation of serum pepsinogenⅠ(PGⅠ),gastrin-17(GS-17),and tumor necrosis factor-α(TNF-α)with peptic ulcer(PU)infected by Helicobacter pylori(HP).Methods A total of 132 patients with PU were selected.According to presence or absence of infection with HP,they were divided into two groups:the PU with HP infection group(n=75)and the PU without HP infection group(n=57).There were 29 cases with gastric ulcer and 46 cases with duodenal ulcer in the PU with HP infection group,and there were 30 cases with gastric ulcer and 27 cases with duodenal ulcer in the PU without HP infection group.In addition,47 healthy individuals who had undergone physical examinations in the hospital during the same period were selected as the health examination group.The levels of serum PGⅠ,GS-17 and TNF-αwere compared in the three groups.The serum PGⅠ,GS-17 and TNF-αlevels of patients with different ulcer types between the PU with HP infection group and the PU without HP infection group were compared.Logistic regression analysis was used to explore the relationship between serum PGⅠ,GS-17,TNF-αlevels and PU infected by HP.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum PGⅠ,GS-17,TNF-αand the combined detection of the three in the diagnosis of PU infected by HP.Results The levels of PGⅠ,GS-17 and TNF-αin the PU with HP infection group and the PU without HP infection group were significantly higher than those in the health examination group.The levels of serum PGⅠ,GS-17 and TNF-αin the PU with HP infection group were higher than those in the PU without HP infection group(P<0.01).The serum GS-17 level of patients with gastric ulcer in PU with HP infection group was lower than that in patients with duodenal ulcer(P<0.01).Levels of serum PGⅠ,GS-17 and TNF-αin patients with gastric ulcer and duodenal ulcer in the PU with HP infection group were higher than those with gastric ulcer and duodenal ulcer in the PU without HP group(P<0.01).Logistic regr
作者
刘东涛
李兵
孙坤
LIU Dong-tao;LI Bing;SUN Kun(Department of Gastroenterology and Anorectal Surgery,Chongzhou People's Hospital,Chongzhou,Sichuan 611230,China)
出处
《临床误诊误治》
CAS
2021年第3期58-63,共6页
Clinical Misdiagnosis & Mistherapy
基金
四川省科技计划项目(2019FZ0039)。
