摘要
目的探讨来曲唑联合炔雌醇环丙孕酮治疗多囊卵巢综合征的整体获益,分析联合用药对促排卵的改善效果。方法收集2018年2月-2020年2月于该院接受常规治疗+来曲唑+炔雌醇环丙孕酮治疗的58例多囊卵巢综合征患者作为观察组,同期于该院接受常规治疗+炔雌醇环丙孕酮治疗的58例多囊卵巢综合征患者作为对照组,连续治疗3个月后评价效果。治疗前、治疗3个月时,检测并比较两组性激素[催乳素(PRL)、卵泡刺激素(FSH)、黄体生成素(LH)、孕酮(P)、雌二醇(E2)及睾酮(T)];治疗结束后,记录并对比两组排卵及妊娠情况;治疗期间,记录两组不良反应。结果治疗3个月后,两组的PRL、FSH、LH及T水平均较治疗前降低,E2、P水平较治疗前升高,且观察组PRL、FSH、LH及T水平低于对照组,E2、P水平高于对照组(P<0.05);治疗期间,两组腹痛腹泻、恶心呕吐、头痛、体质量增加等不良反应发生率比较,差异无统计学意义(P>0.05)。结论来曲唑联合炔雌醇环丙孕酮治疗多囊卵巢综合征较炔雌醇环丙孕酮单独使用获益更高,更利于改善患者病情、提高排卵率及妊娠率,且联合用药不会增加不良反应,安全可靠。
Objective To explore the total effect of letrozole combined with ethinylestradiol and cyproterone acetate in treatment of polycystic ovary syndrome( PCOS),analyze the improving effect of ovulation induction of combination drug therapy. Methods From February 2018 to February 2020,58 patients with PCOS treated by routine therapy,letrozole,ethinylestradiol and cyproterone acetate were selected as observation group,58 patients with PCOS treated by routine therapy and ethinylestradiol and cyproterone acetate were selected as control group. The clinical effects after three months of treatment in the two groups were evaluated. Before treatment and at three months after treatment,the levels of prolactin( PRL),follicle-stimulating hormone( FSH),luteinizing hormone( LH),progesterone( P),estradiol( E2),and testosterone( T) in the two groups were detected and compared. After treatment,the ovulation and pregnancy statuses in the two groups were recorded and compared. In the course of treatment,the adverse reactions in the two groups were recorded. Results After three months of treatment,the levels of PRL,FSH,LH,and T in the two groups were lower than those before treatment,the levels of E2 and P in the two groups were higher than those before treatment,the levels of PRL,FSH,LH,and T in observation group were lower than those in control group,the levels of E2 and P in observation group were higher than those in control group,there were statistically significant differences( P<0. 05). In the course of treatment,there was no statistically significant difference in the incidence rate of adverse reactions between the two groups( P>0. 05). Conclusion Compared with single application of ethinylestradiol and cyproterone acetate,the curative effect of letrozole combined with ethinylestradiol and cyproterone acetate in treatment of PCOS is better,which can improve condition of patients,increase ovulation rate and pregnancy rate,letrozole combined with ethinylestradiol and cyproterone acetate cannot increase adverse reactions,the therap
作者
李可君
陈绍正
LI Ke-Jun;CHEN Shao-Zheng(Baodi Clinical College,Tianjin Medical University,Tianjin,301800,China)
出处
《中国妇幼保健》
CAS
2021年第4期856-860,共5页
Maternal and Child Health Care of China
关键词
多囊卵巢综合征
来曲唑
炔雌醇环丙孕酮
性激素
促排卵
Polycystic ovary syndrome
Letrozole
Ethinylestradiol and cyproterone acetate
Sex hormone
Ovulation induction
