摘要
目的:观察当归调经养血合剂治疗卵巢储备功能下降的临床疗效。方法:将60例气血两虚型卵巢储备功能下降患者随机分为观察组与对照组各30例。观察组自月经第5天开始予当归调经养血合剂治疗,每次100 mL,早、晚分服,到下次月经来潮第1天停药。对照组于月经第5天开始予戊酸雌二醇片1 mg,每天1次,连续21 d,服用戊酸雌二醇片的第11天予黄体酮胶囊100 mg,每天2次,连续10 d。1个月经周期为1个疗程,共3个疗程。治疗3个月经周期后,观察2组患者的中医证候积分、卵泡刺激素(FSH)、黄体生成激素(LH)、雌二醇(E2)、抗苗勒管激素(AMH)、双侧卵巢面积以及窦卵泡数(AFC)。结果:临床疗效总有效率观察组83.33%,对照组76.67%,2组总有效率比较,差异无统计学意义(P>0.05)。与本组治疗前比较,观察组月经量明显增多,中医证候积分明显降低(P<0.01),对照组无明显变化(P>0.05);2组FSH、LH水平均明显降低,AMH均明显升高,卵巢面积明显增大,AFC均明显增多,差异均有统计学意义(P<0.01),E2均较前无明显变化(P>0.05)。治疗后,与对照组比较,观察组月经量明显增多,中医证候积分明显降低(P<0.05);2组FSH、LH、E2、AMH、卵巢面积、AFC比较,差异均无统计学意义(P>0.05)。观察组不良反应总发生率6.67%,对照组20.0%,2组比较,差异有统计学意义(P<0.05)。结论:当归调经养血合剂治疗气血两虚型卵巢储备功能下降能显著改善卵巢功能,不良反应少。
Objective:To observe the clinical effect of Danggui Tiaojing Yangxue mixture for diminished ovarian reserve.Methods:A total of 60 cases of patients with diminished ovarian reserve function of qi-blood deficiency type were randomly divided into the observation group and the control group,30 cases in each group.The observation group was treated with Danggui Tiaojing Yangxue mixture every morning and evening from the 5th day of menstruation,100 mL each time,and stopped treatment on the 1st day of the next menstruation.The control group was given estradiol valerate tablets for 21 consecutive days from the 5th day of menstruation,1 mg each time,once a day;on the 11th day of taking estradiol valerate tablets,100 mg progesterone capsules were added into the treatment of the control group twice a day for 10 consecutive days.Both groups were treated for three courses,one menstrual cycle being a course.After three menstrual cycles,the Chinese medicine syndrome scores,follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),antimullerian hormone(AMH),bilateral ovarian area,and antral follicle count(AFC)were observed in the two groups.Results:The total effective rate was 83.33%in the observation group,and 76.67%in the control group,there being no significance in the difference(P>0.05).When compared with those before treatment,menstrual volume in the observation group was significantly increased,and Chinese medicine syndrome scores were significantly decreased(P<0.01);no significant change was found in menstrual volume and the scores in the control group before and after treatment(P>0.05).After treatment,in the two groups,the levels of FSH and LH were significantly decreased,and AMH,ovarian area and AFC were significantly increased,differences being significant(P<0.01);no significant change was found in the comparison of E2 before and aftertreatment(P>0.05). After treatment,when compared with those in the control group,in the observation group,menstrualvolume was significantly increased, and Chinese medicine sy
作者
梁韵茹
李孔益
李妙华
许巧莹
杨开洪
许玉冰
何小利
彭清慧
LIANG Yunru;LI Kongyi;LI Miaohua;XU Qiaoying;YANG Kaihong;XU Yubing;HE Xiaoli;PENG Qinghui
出处
《新中医》
CAS
2021年第3期90-94,共5页
New Chinese Medicine
基金
广东省中医药局科研项目(20191382)。
关键词
卵巢储备功能下降
当归调经养血合剂
卵泡刺激素
黄体生成激素
雌二醇
抗苗勒管激素
双侧卵巢面积
窦卵泡数
Diminished ovarian reserve
Danggui Tiaojing Yangxue mixture
Follicle-stimulating hormone
Luteinizing hormone
Estradiol
Anti-mullerian hormone
Bilateral ovarian area
Antral follicle count
