摘要
背景:干细胞在椎间盘退变中的治疗一直是研究热点,通过应用文献计量学分析软件对该领域众多文献数据进行共现和共被引分析,可以一定程度上预测和分析该领域的研究现状以及发展趋势。目的:采用文献计量可视化分析法分析干细胞在椎间盘退变治疗中的研究现状及发展趋势。方法:通过科学引文索引数据库核心合集检索1999至2020年关于干细胞在椎间盘退变治疗中的文献,采用文献计量学方法对文献数据进行统计分析,并结合Citespace 5.6.R5和VOSviewer 1.6.15软件进行可视化图谱绘制,分析干细胞在椎间盘治疗中的研究现状及发展趋势。结果与结论:①共纳入613篇文献,干细胞在椎间盘治疗研究中的发文量呈逐年上升的趋势,其中中国和美国分别以发文量232篇和174篇排名前2位;②美国总被引频次(5522)、h指数(42)和中介中心性值(0.75)位居首位,均高于第2位的中国(3169,28,0.16);③共被引排名前10的参考文献分别从多个方面介绍了骨髓间充质干细胞治疗椎间盘退变的研究,其中7篇均与骨髓间充质干细胞髓核样诱导分化有关,2篇涉及椎间盘再生治疗中最佳细胞来源和细胞载体构建,1篇与退变椎间盘再生治疗的临床试验研究有关;④参考文献共被引时间线图表明:以聚类“间充质干细胞”“脊索细胞”“终板”“脂肪来源间充质干细胞”发表的参考文献最多,根据聚类参考文献发表的年份来看,聚类“脊索细胞”“脊索”和“注射”发表的参考文献年份最新;⑤聚类关键词“椎间盘退变”“迁移”“脊索细胞”“京尼平”和“水凝胶”与上述聚类对应,由此印证了当前的研究热点为:间充质干细胞髓核样分化、椎间盘再生治疗中的最佳细胞来源和细胞载体构建和椎间盘再生治疗的临床有效性和生物安全性;⑥同时发现从2017至2019年新出现的突现关键词有5个,分别是“注射”
BACKGROUND:The treatment of stem cells in intervertebral disc degeneration has always been a research hotspot.It is possible to predict and analyze the research status and development trend of this field to a certain extent,applying bibliometric analysis software to perform co-occurrence and co-citation analysis of numerous literature data in this field.OBJECTIVE:To analyze research status and development trend of stem cells in the treatment of intervertebral disc degeneration by bibliometric visualization analysis.METHODS:The authors retrieved the literature on stem cells in the treatment of intervertebral disc degeneration from 1999 to 2020 through the core collection of Web of Science,and used bibliometrics methods to conduct statistical analysis on the literature data,combined with Citespace 5.6.R5 and VOSviewer 1.6.15 software to transform the visualization atlas,analyze the research status and development trend of stem cells in the treatment of intervertebral disc.RESULTS AND CONCLUSION:(1)A total of 613 articles were included.The number of publications of stem cells in intervertebral disc treatment research is increasing year by year.Among them,China and the United States rank first and second with 232 and 174 publications respectively.(2)The United States has a total citation frequency(5522),h index(42),and betweenness centrality(0.75)ranks first,both higher than the second place in China(3169,28,0.16).(3)The top ten cited references introduced the research on the treatment of intervertebral disc degeneration with microscopic mesenchymal stem cells from various aspects,and seven of them were related to nucleus pulposus like differentiation of bone marrow mesenchymal stem cells.Two papers are related to the best cell source and cell carrier generation in the treatment of intervertebral disc regeneration.One is related to the clinical trial study of the treatment of degenerative disc regeneration.(4)The timeline chart of reference co-citation shows that the most references are published in clusters of“Mes
作者
李秋江
房晓敏
王胤斌
胡学华
蔡利军
Li Qiujiang;Fang Xiaomin;Wang Yinbin;Hu Xuehua;Cai Lijun(Third Clinical Medical College of Ningxia Medical University(People’s Hospital of Ningxia Hui Autonomous Region),Yinchuan 750002,Ningxia Hui Autonomous Region,China;The First Clinical Medical College of Northwest University for Nationalities(People’s Hospital of Ningxia Hui Autonomous Region),Lanzhou 730000,Gansu Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第31期5000-5011,共12页
Chinese Journal of Tissue Engineering Research
基金
2017年中央高校基本科研业务费专项资金项目(31920170183),项目负责人:蔡利军。
关键词
干细胞
椎间盘
髓核
细胞
炎症
凋亡
文献计量学
可视化图谱
stem cells
intervertebral disc
nucleus pulposus
cells
inflammation
apoptosis
bibliometrics
visualization atlas
