摘要
目的:探究氨酚羟考酮缓释片应用于晚期恶性肿瘤患者中疼痛缓解效果,并观察其对患者生活质量的影响。方法:选取笔者所在医院2018年4月-2020年4月收治的晚期恶性肿瘤患者92例为探究对象,依据随机数字表法,将入选患者分成氨酚组与吗啡组,其中吗啡组(n=46)行吗啡制剂镇痛,氨酚组(n=46)行氨酚羟考酮缓释片镇痛。观察两组镇痛效果、生活质量及其不良反应发生情况。结果:氨酚组镇痛总有效率为93.48%,高于吗啡组的78.26%,差异有统计学意义(P<0.05)。用药前两组生活质量各项评分比较差异均无统计学意义(P>0.05),用药后两组食欲、睡眠质量及精神状态评分均高于用药前,且氨酚组评分均高于吗啡组,差异均有统计学意义(P<0.05)。用药前两组KPS评分比较差异无统计学意义(P>0.05);用药后氨酚组评分高于吗啡组,差异有统计学意义(P<0.05)。氨酚组便秘、口干、尿潴留、皮疹发生率均低于吗啡组,差异均有统计学意义(P<0.05)。结论:氨酚羟考酮缓释片对晚期恶性肿瘤具有理想的镇痛效果,其能够显著减少患者不良反应,安全性高,有效提高生活质量。
Objective:To investigate the pain relief effect of Oxycodone Sustained-release Tablets in patients with advanced malignant tumor,and to observe its influence on the quality of life of patients.Method:A total of 92 patients with advanced malignant tumor admitted to the hospital of the author from April 2018 to April 2020 were selected as the research objects.According to the random digital table method,the patients were divided into the Aminophenol group and the Morphine group,the Morphine group(n=46)was given Morphine preparation for analgesia,and the Aminophen group(n=46)was given Oxycodone Sustainedrelease Tablets for analgesia.The analgesic effect,quality of life and adverse reactions of the two groups were observed.Result:The total effective rate of analgesia in the Aminophen group was 93.48%,which was higher than that in the Morphine group(78.26%),the difference was statistically significant(P<0.05).There were no significant differences in quality of life scores between the two groups before medication(P>0.05),after medication,the scores of appetite,sleep quality and mental state in the two groups were higher than those before medication,and the scores in the Aminophen group were higher than those in the Morphine group,the differences were statistically significant(P<0.05).There was no significant difference in KPS scores between the two groups before treatment(P>0.05),the score in the Aminophen group was higher than that in the Morphine group,the difference was statistically significant(P<0.05).The incidence of constipation,dry mouth,urinary retention and rash in the Aminophen group was lower than that in the Morphine group,the difference was statistically significant(P<0.05).Conclusion:Oxycodone Sustained-release Tablets has ideal analgesic effects on advanced malignant tumors,which can significantly reduce adverse reactions in patients with high safety and effectively improve the quality of life.
作者
王伟
WANG Wei(Zhangye Ganzhou District People’s Hospital,Zhangye 734000,China)
出处
《中外医学研究》
2021年第6期112-114,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
氨酚羟考酮缓释片
吗啡制剂
晚期恶性肿瘤
疼痛
生活质量
安全性
Oxycodone Sustained-release Tablets
Morphine preparation
Advanced malignant tumor
Pain
Quality of life
Safety
