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益气散结法联合化疗治疗转移去势抵抗性前列腺癌的疗效观察 被引量:3

Clinical Observation of Yiqi Sanjie combined with Chemotherapy in Metastatic Castration-resistant Prostate Cancer
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摘要 目的探讨益气散结法联合化疗治疗转移去势抵抗性前列腺癌(metastatic castration-resistantprostate cancer,mCRPC)的有效性及安全性。方法将32例mCRPC患者,1∶1随机分为益气散结法联合多西他赛化疗研究组和单纯多西他赛化疗组。根据前列腺癌工作组PCWG-2标准进行疗效评价,比较2组无疾病进展生存期(progress free survival,PFS)、PSA反应率,并进行安全性评价。采用FACT-P问卷调查患者生活质量情况。结果研究组的中位PFS略长于对照组(7.4 m vs 6.6 m),但无统计学差异(P>0.05)。4周期治疗后,2组PSA水平均较治疗前有显著下降(P<0.05)。益气散结法研究组PSA反应率64.29%,对照组38.46%。安全性方面,研究组中性粒细胞减少症、疲劳发生率显著低于对照组(P<0.05)。生活质量评分2组患者均有明显下降(P<0.05)。结论益气散结法联合多西他赛方案化疗能较好提高mCRPC患者的生活质量,降低化疗毒性,改善生存,但仍需大样本随机对照临床研究加以证实。 Objective To evaluate the efficacy and security of the combination of Yiqi Sanjie and chemotherapy for metastatic castration resistance prostate cancer.Methods 32 mCRPC patients were randomly divided into Yiqi Sanjie combined with docetaxel chemotherapy group and docetaxel alone group.The efficacy was evaluated according to the criteria PCWG-2 the prostate cancer working group,and the disease-free progression survival(PFS),PSA response rate and safety were compared between the 2 groups.The quality of life of the patients was investigated by FACT-P questionnaire.Results The median PFS of the study group was slightly longer than that of the control group(7.4 m vs 6.6m),but there was no statistical difference(P>0.05).PSA levels decreased significantly in both groups after 4 cycles of treatment(P<0.01).PSA reaction rate was 64.29%in the study group and 38.46%in the control group.In safety,the incidence of neutropenia and fatigue in the study group was significantly lower than in the control group(P<0.05).The quality of life scores were significantly decreased in both groups(P<0.05).Conclusion Yiqi Sanjie combined with docetaxel regimen chemotherapy can improve the quality of life of mCRPC patients,reduce chemotherapy toxicity and improve survival,but it still needs to be confirmed by large sample randomized controlled clinical study.
作者 王雅琦 邱志敏 颜伟 郑智 WANG Yaqi;QIU Zhimin;YAN Wei(Jiangxi Cancer Hospital,Nanchang,330029)
机构地区 江西省肿瘤医院
出处 《实用癌症杂志》 2021年第2期321-324,共4页 The Practical Journal of Cancer
基金 江西省卫生计生委中医药科研课题(编号:2016A114)。
关键词 益气散结法 转移去势抵抗性前列腺癌 化疗毒性 Yiqi Sanjie Metastatic castration resistant prostate cancer Chemotherapy toxicity
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