摘要
目的:探讨盐酸纳布啡复合丙泊酚用于门诊人工流产术的疗效、术后镇痛效果及安全性。方法:收集2017年1月~2019年12月于本院行门诊人工流产术的200例育龄女性,按照随机数字表法分为对照组(仅注射生理氯化钠溶液与丙泊酚)和研究组(采用盐酸纳布啡复合丙泊酚麻醉),各100例。分析不同麻醉药物在人工流产术中的疗效、术后镇痛效果及不良反应发生情况。结果:研究组麻醉优率高于对照组,有统计学差异(P <0.05);但两组麻醉优良率比较无统计学差异(P> 0.05)。两组平均动脉压(MAP)与心率(HR)基本呈先降低再升高的趋势,入宫颈口开始吸宫(T_(2))、手术结束时(T_(3))的MAP与HR低于麻醉诱导前(T_(0)),有统计学差异(P <0.05)。两组血氧饱和度(SpO_(2)) T_(0)~T_(4)基本呈上升趋势,组间比较无统计学差异(P> 0.05)。研究组麻醉起效时间、苏醒时间均短于对照组,丙泊酚用量高于对照组,术后5、30 min的VAS评分低于对照组,有统计学差异(P <0.05)。两组不良反应发生率比较无统计学差异(P> 0.05)。结论:盐酸纳布啡复合丙泊酚用于门诊人工流产术疗效较佳,术后镇痛效果良好,且具有较高的安全性。
Objective:To discuss the treatment effect,postoperative analgesia effects and safety of nalbuphine hydrochloride plus propofol in outpatient artificial abortion.Methods:200 women at childbearing age who underwent artificial abortion in our outpatient department from January 2017 to December 2019 were included in the study and divided into control group(n=100)and research group(n=100),according to the random number table methods.Control group was treated with physiological sodium chloride solution and propofol,while research group with nalbuphine hydrochloride and propofol.Treatment effects,postoperative analgesia effects and adverse reactions were analyzed.Results:The excellent anesthesia rate in research group was higher than that in control group,with statistically significant difference(P<0.05);the good anesthesia rate between two groups showed no significant difference(P>0.05);Mean arterial pressure(MAP)and heart rate(HR)of both groups were declined and then increased;MAP and HR at the beginning of suction(T 2)and the end of operation(T 3)were lower than those before anesthesia induction(T(0)),with statistical significant difference(P<0.05);SpO 2(pulse oxygen saturation)levels of both groups showed an increasing tendency at T_(0) to T_(4),but without significant differences between two groups(P>0.05);Onset time and awakening time of anesthesia in research group were shorter than control group;Dosage of propofol in research group was higher than control group;After 5 min and 30 min of surgery,visual analogue scale(VAS)scores in research group were lower than control group,with statistically significant difference(P<0.05);Adverse event rate between two groups was not significantly different(P>0.05).Conclusion:Nalbuphine hydrochloride combined with propofol can effectively improve the treatment effects,postoperative analgesia effects and safety in outpatient artificial abortion.
作者
郭文姗
张瑞圃
赵端
GUO Wen-shan;ZHANG Rui-pu;ZHAO Duan(Department of Anesthesiology,the Third Affiliated Hospital of Luohe Medical College,Luohe 462000,China)
出处
《中国合理用药探索》
CAS
2021年第2期56-59,共4页
Chinese Journal of Rational Drug Use
关键词
盐酸纳布啡
丙泊酚
门诊
人工流产术
镇痛效果
安全性
nalbuphine hydrochloride
propofol
outpatient
artificial abortion
analgesia effects
safety
