摘要
目的观察心脾两虚型不寐患者血清激素水平的变化.方法选择2018年3月至2019年3月天津市南开医院收治的失眠患者作为研究对象,其中中医辨证为单纯心脾两虚型不寐组20例,心脾两虚型不寐伴抑郁组20例;以同期在本院体检的健康志愿者20例为健康对照组.比较3组研究对象皮质醇(CORT)、促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)水平的差异.结果单纯心脾两虚型不寐组和心脾两虚型不寐伴抑郁组患者的CORT、CRH、ACTH水平均明显高于健康对照组〔CORT(nmol/L):384.30±11.50、413.00±15.95比284.80±30.25,CRH(ng/L):13.90±2.15、14.85±1.60比11.15±1.57,ACTH(ng/L):15.10±1.55、17.23±1.45比12.38±1.37,均P<0.05〕;且心脾两虚型不寐伴抑郁组患者上述指标水平均明显高于单纯心脾两虚型不寐组(均P<0.05).结论心脾两虚型不寐患者CORT、CRH、ACTH水平升高,推测心脾两虚型不寐与下丘脑-垂体-肾上腺(HPA)轴的过度活跃有关.
Objective To observe the changes of serum hormone levels in patients with insomnia accompanied by syndrome of heart and spleen deficiency type.Methods The insomnia patients admitted to Tianjn.Nankai Hospital during March 2018 to March 2019 were selected as the research objects;according to differentiation of syndromes in traditional Chinese mediceine(TCM),there were 20 cases with insomnia in simple heart and spleen deficiency type group and 20 cases with insomnia in depression of heart and spleen deficiency type group:20 cases of healthy volunteers having taken physical examinations in our hospital during the same period were included in the healthy control group.The levels of cortisol(CORT),corticotropin releasing hormone(CRH)and adrenocorticotropic hormone(ACTH)in the three groups were compared.Results The levels of CORT,CRH and ACTH in insomnia of simple heart and spleen deficiency type group and insomnia with depression of heart and spleen deficiency type group were significantly higher than those in healthy control group[CORT(nmol/L):384.30±11.50,413.00±15.95 vs.284.80±30.25,CRH(ng/L):13.90±2.15,14.85±1.60 vs.11.15±1.57,ACTH(ng/L):15.10±1.55,17.23±1.45 vs.12.38±1.37,all P<0.05];the levels of CORT,CRH and ACTH in insomnia with depression of heart and spleen deficiency type group were significantly higher than those of insomnia of simple heart and spleen deficiency type group(all P<0.05).Conclusions The CORT,CRH and ACTH levels are increased in insomnia patients of heart and spleen deficiency type.It is speculated that the insomnia of heart and spleen deficiency type is related to hyperactivity of hy pothalamic-pituitary-adrenal(HPA)axis.
作者
吴新秀
王珩
Wu Xinxiu;Wang Heng(Tianjin University of Chinese Medicine,Tianjin 301600,China;Tianjin Nankai Hospital,Tianjin 300110,China)
出处
《中国中西医结合急救杂志》
CAS
CSCD
北大核心
2020年第6期673-675,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
天津市中医中西医结合科研项目(2019041)。
关键词
不寐
心脾两虚型
下丘脑-垂体-肾上腺轴
激素水平
Insomnia
Heart and spleen deficiency type
Hypothalamic-pituitary-adrenal axis
Hormone levels
