摘要
目的探讨术前用血栓弹力图(TEG)与常规凝血指标监测凝血功能对胃癌患者的预后价值。方法对比136例术前胃癌患者(观察组)与120例健康体检者(对照组)TEG和常规凝血指标的差异,并比较3种病理分组。结果相比对照组,观察组Angle值,MA值、CI值、D-D值、Fg值、PLT值增大,R值和K值减小(P<0.05)。肿瘤浸润深浅、有无淋巴结转移、有无神经侵犯分组与对照组两两比较,K值、Angle值、CI值、D-D值和Fg值差异均有统计学意义(P<0.05);MA值在早期组、无淋巴结转移组、无神经侵犯组均与对照组比较差异无统计学意义(P>0.05),其余各组差异均有统计学意义(P<0.05);R值在肿瘤浸润深浅、有无淋巴结转移、有无神经侵犯分组比较差异无统计学意义(P>0.05),其余各组差异均有统计学意义(P<0.05)。结论胃癌患者随着肿瘤浸润加深、淋巴结转移、神经侵犯,术前高凝程度更甚。联合TEG和常规凝血指标监测患者凝血功能,采取有效治疗方案,可改善预后。
Objective To explore the prognostic value of preoperative thromboelastography( TEG) and conventional coagulation tests to monitor the coagulation function in the patients with gastric cancer. Methods The data between 136 preoperative patients with gastric cancer( observation group) and 120 healthy subjects( control group) in two tests were compared,and gastric cancer in three different clinical-pathological types were also compared. Results Compared with the control group,Angle,MA,CI,D-D,FG and PLT values of the observation group increased,while the R and K values decreased( P <0. 05). The depth of tumor invasion,lymph node metastasis and nerve invasion were compared with the control group in pair-wise,and there was statistical significance on the difference in K,Angle,CI,D-D and FG values( P < 0. 05). The MA value in the early group,no lymph node metastasis group and no nerve invasion group had no statistical significance on the difference compared with the control group( P > 0. 05),and the other groups had statistical significance( P < 0. 05). There was no statistical significance on the difference in R value among groups with or without tumor invasion depth,lymph node metastasis or nerve invasion( P > 0. 05),and there was statistical significance on the differences among other groups( P < 0. 05). Conclusion With the deepening of tumor infiltration,lymph node metastasis and nerve invasion,the preoperative hypercoagulability of patients with gastric cancer is more severe. Combining TEG and routine coagulation indicators to monitor patients’ coagulation function and adopting effective treatment can improve the prognosis.
作者
戚央聪
王磊
周薇
马幼丽
QI Yang-cong;WANG Lei;ZHOU Wei;MA You-li(Department of Blood Transfusion,Ningbo Medical Center Lihuili Hospital,Ningbo,Zhejiang 315040,China)
出处
《中国卫生检验杂志》
CAS
2021年第3期322-326,共5页
Chinese Journal of Health Laboratory Technology
基金
浙江省血液安全研究重点实验室开放课题资助项目(2018KF008)
关键词
血栓弹力图
胃癌
凝血功能
高凝状态
Thromboelastography
Gastric cancer
Coagulation function
Hypercoagulability
