摘要
目的测定健康成年男性血栓弹力图(TEG)的参考值范围,并与厂家提供的数据进行比较。方法采集60例北京地区中国健康成年男性志愿者外周静脉血,应用西芬斯血栓弹力图仪LEPU-8800(北京乐普)分别测定凝血反应时间(R)、凝血形成时间(K)、凝固角(a-Angle)、30min纤维蛋白溶解率(LY30)、综合凝血指数(CI)、二磷酸腺苷(ADP)诱导的血小板抑制率及MA值。结果 60例志愿者平均年龄(24.84±4.21)岁,TEG各参数范围分别为R:4.89~10.77min,K:1.31~4.05min,a-Angle:42.64°~66.16°,MA:41.35~62.39mm,LY30:―2.35%~1.95%,CI:―7.12~0.32。4项主要指标(R、K、a-Angle、MA)中53.3%(32/60)的志愿者至少有1项指标在厂家参考值范围之外。根据Kaufmann分类法,20%(12/60)的志愿者被诊断为凝血异常。ADP抑制率检测37例小于20%,23例约为20%~<50%;MA值检测42例约为31~47mm,18例大于47mm。结论北京地区健康成年男性TEG参数实际参考值与厂家提供的参考值存在差异,实验室应对该地区人群特点建立新的TEG参考值范围。
Objective To verify the reference interval for thromboelastography（TEG）in Chinese healthy adult males in Beijing and compare the value with those provided by the manufacturer.Methods A total of 60 peripheral vein blood samples from Chinese healthy adult males in Beijing were enrolled in this study.The TEG parameters including reaction time（R）,coagulation time（K）,angle（alpha）,LY30,coagulation index（CI）,ADP induced platelet inhibition rate and maximum amplitude（MA）were determined by using a LEPU-8800 device（LEPU,Beijing）.The difference between the actual normal range and manufacturer′s provided reference range was compared.Results The average age of the recruited subjects was（24.84±4.21）years old.The measured ranges of the TEG parameters were R：4.89―10.77 min,K：1.31―4.05 min,alpha-angle：42.64―66.16,MA：41.35―62.39 mm,LY30：―2.35%―1.95%,CI：―7.12―0.32.According to the values of the main indicators including R,K,alpha-angle,and MA,53.3%（32/60）volunteers had at least one indicator outside the manufacturer′s reference range.According to the Kaufmann classification,20%（12/60）volunteers were diagnosed with abnormal coagulation.The ADP inhibition rate was less than 20%in 37 cases,and between 20%―〈50%in 23 cases.The ADP（MA）values ranged between 31―47 mm in 42 cases and47 mm 18 cases.Conclusion The actual range of TEG parameters for Chinese healthy adult males in Beijing is different from the reference interval provided by the manufacturers.It is necessary to establish the reference intervale of TEG parameters according to the characteristics of local population.
作者
秦留安
席少枝
刘佳
刘军
陈韵岱
尹彤
QIN Liuan;XI Shaozhi;LIU Jia;LIU Jun;CHEN Yundai;YIN Tong(Department of Cardiology/National Clinical Research Center for Geriatric Disease, Chinese PLA General Hospital, Beijing 100853, China)
出处
《检验医学与临床》
CAS
2018年第10期1393-1395,共3页
Laboratory Medicine and Clinic
基金
国家老年疾病临床医学研究中心开放课题资助(NCRCG-PLAGH-2017002)
军队后勤科研重点项目资助(BWS17J026)
关键词
健康男性
血栓弹力图
正常参考值
北京地区
healthy malesl thrombelastograghyl reference intervall Beijing region
