摘要
酶因其优异的催化活性和反应特异性被广泛应用于医药领域,但酶稳定性差,不可回收而造成的高昂研究成本限制了其发展。为提高其催化活性和稳定性,各种酶固定化技术不断涌现。近年来,杂化纳米花固定化酶技术因在提高酶稳定性和重复利用度的同时,可大大增强酶活,而受到广泛关注。本文在概述纳米花的特点、合成方法及机理、分类的基础上,重点探讨了其药物研究领域中的应用,并展望了其发展趋势和未来可研究方向,以期为酶联药物应用和新药研发提供新思路。
Enzymes are widely used in the medical field because of their excellent catalytic activity and reaction specificity,but the high research costs caused by the poor stability and irrecoverability of enzymes have limited their development.In order to improve its catalytic activity and stability,various enzyme immobilization technologies are constantly emerging.In recent years,the hybrid nanoflower immobilized enzyme technology has attracted widespread attention because it can greatly enhance enzyme activity in the meanwhile improving enzyme stability and reusability.This article outlines the characteristics,synthesis methods,mechanisms,and classification of nanoflowers,focuses on its application in the field of drug development,and prospects the development trend and future research direction,hoping to provide new ideas of the application of enzyme-linked drugs as well as the research and development of new drugs.
作者
李璟
楚楚
颜继忠
LI Jing;CHU Chu;YAN Ji-zhong(School of Pharmacy,Zhejiang University of Technology,Hangzhou 310014,China)
出处
《药物分析杂志》
CAS
CSCD
北大核心
2021年第1期21-28,共8页
Chinese Journal of Pharmaceutical Analysis
关键词
杂化纳米花
固定化酶
生物催化剂
合成方法
药物研发
应用进展
hybrid nanoflower
immobilized enzyme
biocatalyst
synthetic methods
drug development
application progress
