摘要
目的探讨分析氟西汀联合奥氮平治疗精神分裂阴性症状患者的临床效果。方法选取2019年2月—2020年2月安徽省宿州市第二人民医院收治的80例诊断为精神分裂阴性症状患者作为研究对象,根据随机数字表法分为对照组和观察组,每组各40例。对照组予以奥氮平进行治疗,观察组予以氟西汀联合奥氮平进行治疗。两组均治疗1个月。通过采用阴性症状评定量表(SANS)、药物治疗时不良反应症状量表分析比较两组治疗前和治疗1个月后的治疗效果以及安全性。结果治疗前两组SANS各评分比较,差异无统计学意义(P>0.05),治疗1个月后,两组SANS各评分均较治疗前下降,且观察组低于对照组,差异均有统计学意义(均P<0.05)。两组用药后嗜睡、失眠以及静坐不能不良反应比较,差异无统计学意义(P>0.05),但观察组出现体重增加的比例低于对照组,差异有统计学意义(P<0.05)。结论针对精神分裂阴性症状患者予以氟西汀联合奥氮平治疗可有效改善其阴性症状,提高治疗效果。
Objective To investigate the clinical effect of Fluoxetine combined with Olanzapine in the treatment of patients with negative symptoms of schizophrenia.Methods Eighty patients diagnosed with negative symptoms of schizophrenia admitted to Suzhou City Second People’s Hospital,Anhui Province from February 2019 to February 2020 were selected as the research objects,and were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with Olanzapine,and the observation group was treated with Fluoxetine combined with Olanzapine.Bothgroups were treated for one month.The negative symptom rating scale(SANS)and the adverse reaction symptom scale during drug treatment were used to compare the treatment efficacy and safety of the two groups before and after one month of treatment.Results Before treatment,there was no statistically significant difference in SANS scores between the two groups(P>0.05).After one month of treatment,SANS scores in the two groups were decreased compared with before treatment,and the observation group was lower than the control group,with statistically significant differences(all P<0.05).There was no statistical significance in the comparison of adverse reactions such as drowsiness,insomnia and sedentary inability between the two groups(P>0.05),but the proportion of cases of weight gain in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Fluoxetine combined with Olanzapine treatment for patients with negative symptoms of schizophrenia can effectively improve their negative symptoms and improve the therapeutic effect.
作者
张成珍
时时
宋高峰
ZHANG Chengzhen;SHI Shi;SONG Gaofeng(Department of Psychiatry,Suzhou City Second People’s Hospital,Anhui Province,Suzhou234000,China)
出处
《中国医药导报》
CAS
2021年第5期113-116,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81773518)。
关键词
精神分裂
阴性症状
氟西汀
奥氮平
效果
Schizophrenia
Negative symptoms
Fluoxetine
Olanzapine
Effect
