摘要
长极性菌毛(long polar fimbriae,LPF)是一种最早发现于鼠伤寒沙门菌(Salmonella typhimurium,S.typhimurium)中的CU(chaperone/usher)类型的菌毛,后来该菌毛在其他许多细菌中也得到了鉴定。事实上,LPF不仅作为一种黏附素促进病原体黏附到易感细胞靶向部位,而且参与细菌生物被膜形成和感染组织嗜性。此外,LPF还能增强细菌在宿主细胞中的定植和持续存在能力,并介导宿主的炎症反应。在多种细菌,尤其是在对公共卫生有重要影响的肠出血性大肠杆菌(enterohemorrhagic Escherichia coli,EHEC)O157:H7菌株中,已经充分阐明了LPF是必不可少的毒力因子。现综述LPF的形态特征和分布、操纵子组成和功能、表达调节机制和生物学功能等方面的研究进展,旨在为研究LPF介导的细菌发病机制提供一定的理论基础。
Long polar fimbriae(LPF)was first discovered as a CU(chaperone/usher)type fimbriae in Salmonella typhimurium(S.typhimurium)and has been identified in many other types of bacteria.In fact,LPF not only acts as an adhesin to promote the adhesion of pathogens to the targeted sites of the susceptible cells,but also participates in the formation of bacterial biofilms and bacterial tissue tropism.In addition,LPF can enhance bacterial colonization and persistence in host cells and mediate inflammatory response.It has been well elucidated that LPF is an essential virulence factor in a variety of bacteria,especially in enterohemorrhagic Escherichia coli(EHEC)strain O157:H7.This review summarized the knowledge of the morphological characteristics and distribution of LPF,the composition and function of its operon,the regulation mechanism of LPF expression,and the biological function of LPF,aiming to provide a theoretical basis for exploring the pathogenesis of bacteria mediated by LPF.
作者
丁雪燕
王思权
庞胜美
常雅洁
朱国强
DING Xueyan;WANG Siquan;PANG Shengmei;CHANG Yajie;ZHU Guoqiang(Important Disease Animal and Zoonosis Prevention and Control Collaborative Innovation Center of Jiangsu Province/Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China,College of Veterinary Medicine,Yangzhou University,Yangzhou,Jiangsu 225009,China)
出处
《中国兽医学报》
CAS
CSCD
北大核心
2021年第2期373-380,共8页
Chinese Journal of Veterinary Science
基金
江苏省研究生科研与实践创新计划资助项目(KYCX19_2116)
江苏省重点研发计划资助项目(BE2017342)
国家自然科学基金资助项目(31672579)
扬州市科技局国际合作资助项目(YZ2018154)
江苏省自然科学基金资助项目(BK20150442)
江苏现代农业(奶牛)产业技术体系资助项目(JATS[2018]315)。
关键词
LPF
形态特征
操纵子
调节机制
生物学功能
long polar fimbriae
morphological characteristics
operon
regulation mechanism
biological function
