摘要
目的:探究妊娠糖尿病中肌肉/脂肪质量比与胰岛素抵抗的相关性。方法:选择2015年1月至2020年1月于我院接受治疗的300例产妇为研究对象,按照美国糖尿病学会(American Diabetes Association,ADA)标准将产妇区分为妊娠期糖尿病组(GDM=90例)、妊娠期糖耐量受损组(GIGT=110例)和糖耐量正常组(NGT=100例),分别检测三组产妇的总胆固醇(total cholesterol,TC)、三酰甘油(Triglycerides,TG)、糖化血红蛋白(glycosylated hemoglobin,HbAlc)、肌肉/脂肪质量比(muscle/fat mass ratio,M/F)以及空腹血清胰岛素(fasting insulin,FINS)水平。结果:(1)GDM组患者HbAlc、TC以及TG水平均明显高于GIGT组以及NGT组(P<0.05),GIGT组患者HbAlc、TC以及TG水平均明显高于NGT组(P<0.05);(2)GMD组产妇的M/F明显低于GIGT组产妇,GIGT组产妇明显低于NGT组产妇(P<0.05),而GMD组产妇FINS以及胰岛素抵抗(insulin resistance,IR)明显高于GIGT组,GIGT组明显高于NGT组(P<0.05);(3)胰岛素抵抗(IR)同M/F呈现负相关联系(r=-0.218,P<0.05),同时与HbAlc、TC、TG(r=0.346,r=0.412,r=0.372,P<0.05)等呈现正相关。结论:妊娠女性的M/F值不足同胰岛素抵抗的出现具有一定的相关性,过分强调产妇节食可能会使产妇出现较低的肌肉质量,从而增加GDM的发生风险。
Objective:To explore the relationship between muscle/fat mass ratio and insulin resistance in gestational diabetes mellitus.Methods:300 pregnant women who were treated in our hospital from January 2015 to January 2020 were divided into gestational diabetes group(GDM=90 cases),gestational impaired glucose tolerance group(GIGT=110 cases)and normal glucose tolerance group(NGT=100 cases)according to the standards of American Diabetes Association(ADA).The total cholesterol(TC),triglyceride(TG),glycosylated blood red of the three groups were detected respectively Protein(HbAlc),muscle/fat mass ratio(M/F)and fasting serum insulin(fins)levels.Results:(1)The levels of HbAlc,TC and TG in GDM group were significantly higher than those in GIGT group and NGT group(P<0.05).The levels of HbAlc,TC and TG in GIGT group were significantly higher than those in NGT group(P<0.05).(2)The M/F of GMD group was significantly lower than that of GIGT group,and that of GIGT group was significantly lower than that of NGT group(P<0.05).In GMD group,fins and IR were significantly higher than those in GIGT group,GIGT group was significantly higher than NGT group(P<0.05).(3)IR was negatively correlated with M/F(r=-0.218,P<0.05),at the same time,it was positively correlated with HbAlc,TC,TG(r=0.346,r=0.412,r=0.372,P<0.05).Conclusion:The insufficient M/F value of pregnant women was related to the occurrence of insulin resistance.Overemphasis on maternal diet may lead to lower muscle mass and increase the risk of GDM.
作者
李彦荣
刘华
王伟卓
魏建勋
惠旭东
LI Yan-rong;LIU Hua;WANG Wei-zhuo;WEI Jian-xun;HUI Xu-dong(Department of First Obstetrics Ward,Yan'an University Affiliated Hospital,Yan'an,Shaanxi,716000,China;Department of Second Obstetrics Ward,Yan'an University Affiliated Hospital,Yan'an,Shaanxi,716000,China;Department of Orthopedics,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710000,China)
出处
《现代生物医学进展》
CAS
2020年第24期4718-4721,4700,共5页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81001225)。
关键词
妊娠糖尿病
肌肉/脂肪质量比
胰岛素抵抗
Gestational diabetes mellitus
Muscle/fat mass ratio
Insulin resistance
