摘要
目的探讨阿卡波糖联合西格列汀治疗老年2型糖尿病患者的效果及对胰岛素功能、血糖波动的影响。方法将2018年5月至2020年5月随机分为对照组和观察组,各46例。对照组采用阿卡波糖治疗,观察组采用阿卡波糖联合西格列汀治疗。比较两组治疗前、后的血糖指标、胰岛功能指标及血糖波动指标。结果治疗后,两组的FBG、2 h PG水平及HbA1c均较治疗前降低,且观察组低于对照组(P<0.05)。治疗后,两组的HOMA-β均升高,HOMA-IR均降低,且观察组优于对照组(P<0.05)。治疗后,两组的血糖水平标准差、日平均血糖波动幅度及日间血糖平均绝对差均较治疗前降低,且观察组低于对照组(P<0.05)。结论阿卡波糖联合西格列汀治疗老年2型糖尿病患者,有助于提高患者的血糖控制效果,改善胰岛功能,减轻血糖波动,值得临床推广应用。
Objective To explore the effect of acarbose combined with sitagliptin in the treatment of elderly patients with type 2 diabetes and its influences on insulin function and blood glucose fluctuation.Methods Ninety-two elderly patients with type 2 diabetes admitted from May 2018 to May 2020 were randomly divided into control group and observation group,with 46 cases in each group.The control group was treated with acarbose,and the observation group was treated with acarbose combined with sitagliptin.The blood glucose indexes,islet function indexes and blood glucose fluctuation indexes before and after treatment were compared between the two groups.Results After treatment,FBG,2 h PG levels and HbA1c in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).After treatment,HOMA-βincreased and HOMA-IR decreased in both groups,and those in the observation group were better than the control group(P<0.05).After treatment,the standard deviation of blood glucose level,daily mean amplitude of glycemic excursions and mean absolute difference of daytime blood glucose in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).Conclusion Acarbose combined with sitagliptin in the treatment of elderly patients with type 2 diabetes can help to enhance the effect of blood glucose control,improve islet function and reduce blood glucose fluctuation,which is worthy of clinical promotion and application.
作者
高慧祯
康志强
GAO Huizhen;KANG Zhiqiang(Endocrinology Department,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,China)
出处
《临床医学研究与实践》
2021年第6期37-39,共3页
Clinical Research and Practice
关键词
阿卡波糖
西格列汀
2型糖尿病
胰岛素功能
血糖波动
血糖水平标准差
acarbose
sitagliptin
type 2 diabetes mellitus
insulin function
blood glucose fluctuation
standard deviation of blood glucose level