摘要
目的探讨Rhupus综合征的临床特点。方法收集2015年1月至2019年12月昆明医科大学第二附属医院风湿免疫科21例Rhupus综合征患者(Rhupus组)资料,并随机抽取同期住院的无合并SLE的120例RA患者(RA组)及无合并RA的45例SLE患者(SLE组)作为对照组,比较三组临床特点。结果21例Rhupus综合征患者均为女性,61.9%以RA起病,起病年龄小于RA组,与SLE组比较差异无统计学意义(P>0.05),病程均长于对照组。与RA组相比,手关节炎、多关节炎、对称性关节炎的发生率和RF阳性率的差异无统计学意义(P>0.05);骨侵蚀、关节畸形、类风湿结节的发生率高于RA组,抗CCP、AKA、APF抗体的阳性率则低于RA组,差异有统计学意义(P<0.05)。与SLE组相比,Rhupus组面部红斑的发生率低于对照组,差异有统计学意义(P<0.05);多浆膜腔积液、肾脏及血液系统受累的发生率及ANA、抗dsDNA抗体的阳性率的差异无统计学意义(P>0.05)。结论Rhupus综合征多以RA起病,关节炎表现重,ANA、抗CCP抗体及RF阳性率较高,有助于诊断。
Objective To analyse the clinical features of Rhupus syndrome.Methods The medical records of 21 Rhupus syndrome patients who were admitted to the Second Affiliated Hospital of Kunming Medical University from 2015 to 2019 were analysed retrospectively.One hundred and twenty RA patients and 45 SLE patients from our Unit were randomly selected as the controls.The data of patients in the three groups were compared.Results Twenty-one patients with Rhupus syndrome were female,61.9%patients were initiallypresented with RA.The age of onset was significantly younger than that of RA(P<0.05),but similar to that of SLE.Rhupus patients had longer diseaseduration than control groups.As compared with RA patients,Rhupus patients had higher incidence of bone erosion,joint defornlity and rheumatoid nodules,lower anti-CCP,AKA and APF antibodies positivity(P<0.05).There were no significant differences in the incidence of hand arthritis,polyarthritis,symmetrical arthritis and RF positivity(P>0.05).As compared with SLE patients,Rhupus patients had less malar erythema while no differences were observed in serositis,kidney,hematological involvement and ANA,antidsDNA antibody positivity(P>0.05).Conclusions Most of the Rhupus patients are firstly presented with RA and with severe arthritis.The positivity of ANA,anti-CCP and RF arehigh,are helpful to the diagnosis.
作者
蔡金云
王娟
孙瑞希
傅萍
CAI Jin-yun;WANG Juan;SUN Rui-xi;FU Ping(Dept.of Rheumatology,The Second Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)
出处
《昆明医科大学学报》
CAS
2021年第2期64-69,共6页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81860287)。
