摘要
概述了马波沙星的理化性质、合成途径、作用机制与体外抗菌活性、安全性以及含量或残留检测方法。马波沙星是动物专用的新型氟喹诺酮类抗菌药,主要通过抑制细菌拓扑异构酶的活性而发挥作用,具有抗菌谱广、安全高效、交叉耐药少等特点,在防治动物疾病领域具有广阔的应用前景。
In this paper,the research progress about physico-chemical properties,synthesis pathway,mechanism,in vitro antibacterial activity,safety and detection methods of marbofloxacin were reviewed.As a new type of fluoroquinolone antibacterial drug,marbofloxacin,with many advantages such as broad antimicrobial spectrum,strong and fast antimicrobial effects,a few adverse reactions and non-cross-resistant,acts mainly by inhibition of bacterial DNA-gyrase,which has a broad application prospect in the field of animal disease prevention and control.
作者
彭文绣
PENG Wen-xiu(China Institute of Veterinary Drug Control,Beijing 100081,China)
出处
《中国兽药杂志》
2021年第2期67-73,共7页
Chinese Journal of Veterinary Drug
关键词
马波沙星
合成途径
体外抗菌活性
安全性
检测方法
marbofloxacin
synthesis pathway
in vitro antibacterial activity
safety
detection methods
