摘要
目的探讨替罗非班对急性脑梗死患者炎性因子及免疫功能的影响。方法选取2017年12月至2019年11月该院就诊的80例急性脑梗死患者为研究对象,分为替罗非班组及常规治疗组,每组各40例。常规治疗组接受拜阿司匹林、氯吡格雷及其他常规治疗,替罗非班组在常规治疗的基础上接受替罗非班治疗。比较治疗前后两组美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力(BI指数)、炎性因子、免疫指标及血小板功能指标变化情况,并观察治疗期间出血发生情况。结果治疗前两组NIHSS评分、BI指数、炎性因子、血小板黏附率、血小板聚集率、免疫指标比较,差异无统计学意义(P>0.05)。与常规治疗组比较,治疗后替罗非班组NIHSS评分、C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血小板黏附率、血小板聚集率、C3、C4水平更低,BI指数、CD4^(+)、CD4^(+)/CD8^(+)水平更高,差异有统计学意义(P<0.05)。两组治疗期间出血不良事件发生率比较,差异无统计学意义(P>0.05)。结论替罗非班可改善脑梗死患者神经和血小板功能,并提高免疫功能、降低炎性反应。
Objective To explore the effect of tirofiban on inflammatory factors and immune function in patients with acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction in this hospital from December 2017 to November 2019 were selected and divided into the tirofiban group and the conventional treatment group,with 40 cases in each group.The conventional treatment group received bayaspirin,clopidogrel and other conventional treatments,and the tirofiban group received tirofiban treatment on the basis of conventional treatment.Compared the changes of National Institutes of Health Stroke Scale(NIHSS)score,ability of daily living(BI index),inflammatory factors,immune indexes and platelet function indexes in the two groups before and after treatment,and observed the occurrence of bleeding during the treatment.Results Before treatment,there was no significant difference in NIHSS score,BI index,inflammatory factors,platelet adhesion rate,platelet aggregation rate,and immune index between the two groups(P>0.05).Compared with the conventional treatment group,NIHSS score,C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),platelet adhesion rate,platelet aggregation rate,C3 and C4 levels in the tirofiban group decreased after treatment,while BI index,CD4^(+),CD4^(+)/CD8^(+)levels increased,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of bleeding adverse events between the two groups during treatment(P>0.05).Conclusion Tirofiban can improve nerve and platelet function in patients with cerebral infarction,improve immune function,and reduce inflammatory response.
作者
李永
刘彬
王荣
LI Yong;LIU Bin;WANG Rong(Department of Neurology,the First People′s Hospital of Suzhou,Suzhou,Anhui 234000,China)
出处
《重庆医学》
CAS
2021年第4期630-633,共4页
Chongqing medicine
基金
安徽省高校科学研究重点项目(KJ2018-A018)。
关键词
替罗非班
脑梗死
炎性因子
免疫活性
出血
tirofiban
brain infarction
inflammatory factors
immunocompetence
hemorrhage
