摘要
目的:研究康莱特注射液联合阿帕替尼治疗晚期胃癌的效果。方法:90例晚期胃癌患者分为两组,每组45例。对照组采用阿帕替尼化疗,试验组在此基础上联合康莱特注射液治疗。比较两组临床疗效、无进展生存期(PFS)、1年生存期(OS)、客观缓解率(ORR)、毒副反应发生率及生活质量改善情况。结果:化疗后比较,两组ORR比较差异无统计学意义(P>0.05);试验组血清白细胞介素2(IL-2)、干扰素-γ(INF-γ)和肿瘤坏死因子-α(TNF-α)水平均低于对照组(P<0.05);试验组0~Ⅳ级贫血、肝功能异常的毒副反应发生率低于对照组,试验组生活质量改善率高于对照组(P<0.05)。随访1年后,试验组PFS、OS均高于对照组(P<0.05)。试验组1年生存率略高于对照组,但差异无统计学意义(P>0.05)。结论:康莱特注射液联合阿帕替尼治疗晚期胃癌患者,可改善血清炎症因子水平、减少毒副反应,提高生活质量。
Objective:To explore the effect of Kanglaite injection in apatinib chemotherapy for patients with advanced gastric cancer.Methods:A total of 90 patients with advanced gastric cancer were randomly divided into control group(apatinib chemotherapy)and experimental group(Kanglaite injection on basis of control group),45 cases in each group.The clinical curative effect,progression-free survival(PFS),1-year overall survival survival(OS),objective response rate(ORR),incidence of side reactions and improvement of quality of life were compared between the two groups.Results:After chemotherapy,there was no significant difference in ORR between experimental group and control group(P>0.05).After chemotherapy,levels of serum interleukin-2(IL-2),tumor necrosis factor-α(TNF-α)and interferon-γ(INF-γ)in experimental group were lower than those in control group(P<0.05).After chemotherapy,incidence of anemia at level 0~IV and abnormal liver function in experimental group was lower than that in control group,while improvement rate of quality of life was higher than that in control group(P<0.05).The patients in both groups were followed up for 1 year.PFS and OS in experimental group were higher than those in control group.The 1-year survival rate in experimental group was higher than that in control group,but the difference was not statistically significant(P>0.05).Conclusion:Kanglaite injection combined with apatinib in the treatment of patients with advanced gastric cancer can improve levels of serum inflammatory factors,reduce side effects,and improve quality of life.
作者
刘登湘
王娜
何莉莉
郭军
孙雅薇
朱晓燕
郭治
靳毅
LIU Deng-xiang;WANG Na;HE Li-li;GUO Jun;SUN Ya-wei;ZHU Xiao-yan;GUO Zhi;JIN Yi(Department of Medicine Oncology,Xingtai People's Hospital,Xingtai 054031,Hebei,China)
出处
《川北医学院学报》
CAS
2021年第1期38-41,共4页
Journal of North Sichuan Medical College
基金
河北省中医药管理局科研计划项目(2018420)。
关键词
胃癌
康莱特注射液
阿帕替尼
治疗效果
Gastric cancer
Kanglaite injection
Apatinib
Treatment effect
