摘要
目的探究低分子肝素联合尿激酶治疗急性肺栓塞(APE)的效果及对凝血系统的影响。方法选取我院收治的116例APE患者,采用随机数字法将其分为对照组(58例,尿激酶溶栓治疗)和观察组(58例,尿激酶溶栓+低分子肝素治疗)。比较两组的治疗效果。结果观察组的治疗总有效率明显高于对照组(P<0.05)。治疗后,两组的PaO2、PaCO2均升高,HR均降低,且观察组明显优于对照组(P<0.05)。治疗后,两组的PT、TT、APTT均延长,FIB水平均降低,且观察组明显优于对照组(P<0.05)。结论低分子肝素联合尿激酶治疗APE的临床效果显著,可改善患者的临床症状和凝血功能。
Objective To explore the effect of low molecular weight heparin combined with urokinase in the treatment of acute pulmonary embolism(APE)and its influence on coagulation system.Methods A total of 116 patients with APE treated in our hospital were selected and divided intocontrol group(58 cases,urokinase thrombolysis treatment)and observation group(58 cases,urokinase thrombolysis+low molecular weight heparin treatment)by random number method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatement in the observation group was significantly higher than that in the control group(P<0.05).After treatment,PaO2 and PaCO2 in the two groups increased,HR decreased,and those in the observation group were significantly better than the control group(P<0.05).After treatment,PT,TT and APTT in the two groups prolonged,the FIB level decreased,and those in the observation group were significantly better than the control group(P<0.05).Conclusion Low molecular weight heparin combined with urokinase in the treatment of APE has a significant clinical effect,which can improve the clinical symptoms and coagulation function of patients.
作者
梁蕾
LIANG Lei(Emergency Department,the People's Hospital of Yancheng District,Luohe 462300,China)
出处
《临床医学研究与实践》
2021年第4期79-81,共3页
Clinical Research and Practice
关键词
低分子肝素
尿激酶
急性肺栓塞
凝血系统
low molecular weight heparin
urokinase
acute pulmonary embolism
coagulation system
