摘要
目的探讨血清和肽素、血管内皮细胞生长因子(VEGF)水平与早期糖尿病肾病(DN)患者疾病严重程度的关系。方法选取2017年2月至2018年1月本院确诊的单纯2型糖尿病患者80例(T2DM组)、24 h尿清蛋白排泄率(UAER)范围30~300 mg/24 h的T2DM患者80例(微量组)、UAER>300 mg/24 h的T2DM患者80例(大量组);对比3组的血清和肽素、VEGF、肾动脉收缩期峰值血流速度(PSV)、舒张期血流速度(EDV)、阻力指数(RI),采用简单线性相关法分析上述指标与UAER的相关性。结果大量组患者的血清和肽素、VEGF水平显著高于微量组、对照组,差异有统计学意义(P<0.05),微量组血清和肽素、VEGF水平显著高于T2DM组,差异有统计学意义(P<0.05);大量组肾动脉PSV、EDV测定值低于微量组、T2DM组(P<0.05),微量组肾动脉PSV、EDV测定值低于T2DM组(P<0.05);大量组患者的肾动脉RI测定值高于微量组、T2DM组(P<0.05),微量组RI测定值高于T2DM组(P<0.05);DN患者的血清和肽素、VEGF与水平与UAER呈现正相关关系(P<0.05),肾动脉PSV、EDV与UARE呈负相关关系(P<0.05),肾动脉RI值与UARE呈显正相关关系(P<0.05)。结论DN患者存在血清和肽素和VEGF水平升高,其可能通过引起肾血管损害参与糖尿病肾病发生及进展过程。
Objective To investigate relationship of copeptin,vascular endothelial growth factor(VEGF)with degree of early diabetic nephropathy(DN).Methods 80 patients with Type 2 diabetes mellitus(T2DM)who had a diagnosis of simple type 2 diabetes were selected into T2DM group,80 patients with T2DM who was complicated by 24 hours of urinary albumin excretion rate(UAER)ranging from 30 to 300 mg/24h were selected in micro-group,80 patients with T2DM who was complicated by UAER>300 mg/24h were selected into large group in our hospital from Feb 2017 to Jan 2018,level of copeptin and VEGF in serum,renal artery systolic peak blood flow velocity(PSV)and diastolic blood flow velocity(EDV),resistance index(RI)were contrasted among three groups.The relationship of copeptin,VEGF,PSV,EDV and RI were analyzed with simple linear correlation analysis in early DN.Results The levels of copeptin and VEGF in serum were significantly higher in the large group than in the micro-group and the T2DM group(P<0.05).The levels of copeptin and VEGF in serum were significantly higher in the micro-group than the T2DM group(P<0.05);PSV and EDV of renal artery were lower in the large group than in the micro-group and the T2DM group(P<0.05).PSV and EDV of renal artery were lower in the micro-group than in the T2DM group(P<0.05);RI was higher in the large group than that in the micro-group and the T2DM group(P<0.05).RI was in the micro-group higher than in the T2DM group(P<0.05).The levels of copeptin and VEGF in serum were positively correlated with UAER(P<0.05),PSV and EDV were negatively correlated with UAER(P<0.05).RI was positively correlated with UAER(P<0.05).Conclusions DN patients have elevated serum levels of copeptin and VEGF,which may be involved in the occurrence and progression of diabetic nephropathy by causing renal vascular damage.
作者
丁卫
冯妍
王秭萱
DING Wei;FENG Yan;WANG Zixuan(Department of Nephrology,Central Hospital of Chaoyang City in Liaoning,Chaoyang,Liaoning,China,122000;Department of Psychology,Liaoning Armed Police Corps Hospital,Shenyang,Liaoning,China,110034;The Second Department of Internal Medicine,Liaoning Armed Police Corps Hospital,Shengyang,Liaoning,China,110034)
出处
《分子诊断与治疗杂志》
2021年第1期95-98,共4页
Journal of Molecular Diagnostics and Therapy
基金
辽宁省科技厅科学技术计划(20172233205)。
关键词
和肽素
血管内皮细胞生长因子
糖尿病肾病
肾动脉
血流参数
Copeptin
Vascular endothelial growth factor
Diabetic nephropathy
Renal artery
Blood flow parameters
