摘要
目的观察三棱针刺血治疗慢性痛风(CG)对内源性肾上腺糖皮质激素水平的影响,探讨三棱针刺血治疗CG的抗炎作用机制。方法76例CG患者,按随机数字表法分为治疗组和对照组,每组38例。对照组采取一般治疗,治疗组在对照组治疗的基础上采用三棱针刺血治疗。比较两组患者临床疗效以及治疗前及治疗3、6个月后疼痛数字评分法(NRS)评分、皮质醇水平、超敏C反应蛋白(hs-CRP)水平、血清尿酸(SUA)水平。结果治疗组治疗总有效率94.74%高于对照组的63.16%,差异有统计学意义(P<0.05)。治疗组治疗前、治疗3个月后、治疗6个月后的NRS评分分别为(6.62±1.21)、(2.16±0.35)、(0.68±0.13)分,对照组治疗前、治疗3个月后、治疗6个月后的NRS评分分别为(6.58±1.28)、(4.M±1.36)、(3.98±1.24)分。治疗前,两组患者NRS评分比较,差异无统计学意义(F>0.05);治疗3个月后,两组患者NRS评分均低于本组治疗前,治疗6个月后治疗组患者NRS评分低于治疗3个月后,且治疗组患者治疗3、6个月后的NRS评分均低于对照组,差异均具有统计学意义(P<0.05)。治疗3、6个月后治疗组皮质醇均高于治疗前,治疗6个月后高于治疗3个月后,且治疗组治疗3、6个月后皮质醇水平均高于对照组,差异均具有统计学意义(P<0.05);对照组患者治疗前后皮质醇水平比较,差异无统计学意义(P>0.05)。两组患者治疗3、6个月后hs-CRP、SUA水平均低于治疗前,治疗6个月后hs-CRP、SUA水平均低于治疗3个月后,且治疗组患者治疗3、6个月后hs-CRP、SUA水平均低于对照组,差异均具有统计学意义(P<0.05)。结论采用三棱针刺血治疗CG,能提高内源性糖皮质激素水平,发挥抗炎作用,减轻CG的炎性反应;能有效降低hs-CRP、SUA水平,减轻患者关节肿痛,改善临床症状,提高临床疗效。
Objective To observe the effect of the triangle-edged needle pricking blood on endogenous adrenal glucocorticoid levels in chronic gout(CG),and discuss the anti-inflammatory mechanism of triangle-edged needle pricking blood on CG.Methods A total of 76 CG patients were divided into triangle-edged needle group and control group according to random numerical table,with 38 cases in each group.The control group was treated with general therapy,and the treatment group was treated with triangle-edged needle pricking blood based on the control group.The clinical efficacy,numerical rating scale(NRS)score,cortisol level,high sensitivity C-reactive protein(hs-CRP)level,serum uric acid(SUA)level before treatment and after 3 and 6 months of treatment were compared between the two groups.Results The total effective rate of treatment 94.74%of the treatment group was higher than 63.16%of the control group,and the difference was statistically significant(P<0.05).Before treatment,3 and 6 months after treatment,the NRS score of the treatment group were(6.62±1.21),(2.16±0.35)and(0.68±0.13)points,which were(6.58±1.28),(4.14±1.36)and(3.98±1.24)points of the control group.Before treatment,there was no statistically significant difference in NRS score between the two groups(P>0.05).3 months after treatment,the NRS score of the two groups were lower than those before treatment,and the NRS score after 6 months of treatment of the treatment group was lower than that of 3 months after treatment,and the NRS score after 3 and 6 months of treatment of the treatment group were lower than those of the control group.The difference was statistically significant(P<0.05).After 3 and 6 months of treatment,the cortisol level of the treatment group was higher than that of the control group,and after 6 months of treatment,it was higher than that after 3 months of treatment,and the cortisol level of the treatment group was higher than that of the control group after 3 and 6 months of treatment.The difference was statistically significant(P<0.05).In
作者
孙上明
宁文瑾
叶青
麦志周
朱晓霞
符云浪
林伟杰
SUN Shang-ming;NING Wen-jin;YE Qing(Foshan First People’s Hospital Chancheng Hospital,Foshan 528061,China)
出处
《中国实用医药》
2021年第3期1-5,共5页
China Practical Medicine
基金
佛山市医学类科技攻关项目(项目编号:2017AB001591),项目名称:三棱针刺血治疗慢性痛风对内源性肾上腺糖皮质激素水平影响的研究。
关键词
慢性痛风
三棱针刺血
内源性肾上腺糖皮质激素
抗炎作用
Chronic gout
Triangle-edged needle pricking blood
Endogenous adrenal glucocorticoid
Anti-inflammatory effect
