摘要
目的探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、癌胚抗原(CEA)在晚期非小细胞肺癌(NSCLC)患者中的预后价值。方法将晚期NSCLC患者135例分为高低NLR组、高低PLR组、高低CEA组,比较组间的一般临床资料。比较NLR、PLR、CEA对晚期NSCLC预后的评估价值。结果低NLR组中位OS明显高于高NLR组(χ^2=10.05,P<0.01)。低PLR组中位OS明显高于高PLR组(χ^2=6.128,P=0.013)。低CEA组中位OS明显高于高CEA组(χ^2=12.18,P<0.01)。NLR、PLR、CEA指标的ROC曲线下面积(AUC)最大的是NLR,为0.761。结论NLR、PLR、CEA均可不同程度的评估晚期NSCLC患者的预后,其中NLR的预测效能最佳。
Objective To investigate the prognostic value of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and carcinoembryonic antigen(CEA)in patients with advanced non-small cell lung cancer(NSCLC).Methods One hundred and thirty-five cases of advanced NSCLC were divided into high and low NLR group,high and low PLR group and high and low CEA group,and the general clinical data among the groups were compared.The evaluation value of NLR,PLR and CEA on the prognosis of advanced NSCLC was compared.Results The median OS of low PLR group was significantly higher than that of high PLR group(χ^2=6.128,P=0.013).The median OS of low CEA group was significantly higher than that of high CEA group(χ^2=12.18,P<0.01).Among NLR,PLR and CEA,the index NLR 0.761 was the largest in the area under the ROC curve(AUC).Conclusion NLR,PLR and CEA can evaluate the prognosis of patients with advanced NSCLC to different degrees,among which NLR has the best predictive efficacy.
作者
鲍欣然
哈敏文
Bao Xinran;Ha Minwen(First Ward of Chest Tumor, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China)
出处
《临床荟萃》
CAS
2021年第2期139-143,共5页
Clinical Focus
