摘要
肝脏是鸡进行脂质代谢的重要场所,脂肪肝综合征是产蛋期母鸡常见的一种亚临床生理性代谢综合征,脂肪肝综合征呈渐进性发展,特别是进入产蛋后期会严重影响母鸡的健康和生产性能,给养殖业带来经济损失。雌激素水平与母鸡产蛋和肝脏脂肪代谢功能密切相关,雌激素的作用主要由雌激素受体(ER)介导。大量的数据表明,ERα和ERβ在哺乳动物的脂质代谢和脂质沉积中扮演不同的角色,但雌激素-ER通路对母鸡脂肪肝发生、发展的影响尚不明确。本文概述了卵黄前体物质合成对肝脏脂肪代谢的影响、雌激素对脂肪肝发生的可能影响以及雌激素-ER通路在母鸡脂肪肝发生过程中的可能分子机制。
Liver is an important place for chickens to carry out lipid metabolism,fatty liver syndrome is a common subclinical physiological metabolic syndrome in laying hens,and the syndrome develops gradually,especially in the late laying stage,which will seriously affect the health and production performance of hens and bring economic losses to the breeding industry.The level of estrogen is closely related to the laying of hens and the function of liver fat metabolism in hens.The effect of estrogen is mainly mediated by estrogen receptor(ER).A large amount of data shows that ERαand ERβplay different roles in lipid metabolism and lipid deposition in mammals,however,the influence of estrogen-ER pathway on the occurrence and development of fatty liver in hens is still unclear.In this review,we summarized the influence of yolk precursor substance synthesis on liver fat metabolism,the possible influence of estrogen on the occurrence of fatty liver,and the possible molecular mechanism of estrogen-ER pathway in the occurrence of fatty liver in hens.
作者
姚宏
胡艳
饶开晴
施寿荣
YAO Hong;HU Yan;RAO Kaiqing;SHI Shourong(Poultry Institute,Chinese Academy of Agricultural Sciences,Yangzhou 225125,China;College of Life Science and Technology,Southwest Minzu University,Chengdu 610041,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2021年第1期85-94,共10页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家重点研发计划课题(2018YFD050130201)
江苏现代农业产业技术体系建设项目(JATS[2019]380)。
