摘要
目的探讨99mTc-3PRGD2 SPECT/CT显像对孤立肺结节(SPN)的诊断价值。方法收集2015年1月至2019年12月SPN患者79例,男51例,女28例;年龄43~81岁,平均年龄(62.39±8.99)岁。所有患者均行99mTc-3PRGD2SPECT/CT平面及融合断层显像,测量SPN感兴趣区(ROI)计数值为T,在SPN对侧正常肺组织内画出与病灶同样大小的ROI,测量其计数值为NT,算出T/NT比值。与穿刺病理检查结果比较,分析99mTc-3PRGD2 SPECT/CT平面及融合断层显像T/NT对SPN的诊断价值。结果与病理检查结果比较,99mTc-3PRGD2 SPECT/CT平面显像良性组和恶性组T/NT分别为2.3±1.4和3.7±2.5,二者比较差异有统计学意义(P<0.05)。99mTc-3PRGD2 SPECT/CT平面显像T/NT比值ROC曲线下面积(AUC)0.734(P<0.05),提示该检查对判断SPN良恶性具有诊断意义。99mTc-3PRGD2 SPECT/CT平面显像T/NT比值最佳临界值为2.825。其诊断SPN良恶性特异度、灵敏度、准确率、漏诊率、误诊率、阴性预测值(PV-)阳性预测值(PV+)、分别为49.1%、95.5%、62.0%、4.5%、50.9%、96.6%、42%。99mTc-3PRGD2 SPECT/CT平面显像与融合断层显像比较,融合断层ROC曲线下面积为0.919(P<0.05),平面显像ROC曲线下面积为0.866(P<0.05),提示断层显像对SPN良恶性诊断的准确度更高。结论99mTc-3PRGD2 SPECT/CT平面及融合断层显像均可对SPN良恶性进行诊断,但融合断层诊断效果更好。
Objective To investigate the value of 99mTc-3PRGD2 SPECT/CT in the diagnosis of solitary pulmonary nodule(SPN).Methods 79 patients with SPN were enrolled in the respiratory department of the Affiliated Hospital of Inner Mongolia Medical University in the January 2015 to December 2019,they were 51 males and 28 females,the average age of 62.39±8.99 years old.All patients were examined by 99mTc-3PRGD2 SPECT/CT,it were planar and c.SPN with region of interest(ROI)were drawed and measured.The ROI In the SPN was named T,the ROI in the contralateral normal lung tissue and in the same size as SPN was named NT,the T/NT ratio were calculated.The pathological results of puncnire were compared.The T/NT values in SPN by 99mTc-3PRGD2 SPECT/CT plane and integrated tomographic images were evaluated.Results Compared with pathological results,99mTc-3PRGD2 SPECT/CT planar imaging showed that T/NT was 2.3±1.4 in benign group and 3.7±2.5 in malignant group,the difference was statistically significant(P<0.05).The area under curve(AUC)of T/NT ratio in 99mTc-3PRGD2 SPECT/CT planar imaging was 0.734(P<0.05),which indicated that tliis examination was significance for the diagnosis of SPN.The best critical value of T/NT ratio by 99mTc-3PRGD2 SPECT/CT planar imaging was 2.825.The specificity,sensitivity,accuracy,missed diagnosis,misdiagnosis,negative predictive value(PV-)and positive predictive value(PV+)with SPN were 49.1%,95.5%,62.0%,4.5%,50.9%,96.6%,42%.To Compared of planar imaging and integrated tomographic imaging by 99mTc-3PRGD2 SPECT/CT,The area under ROC curve of tomographic imaging was 0.919(P<0.05),and that under ROC curve of planar imaging was 0.866(P<0.05),It was suggested that the accuracy was higher in the diagnosis of SPN by integrated tomographic imaging.Conclusion The plane and integrated tomographic unaging by 99mTc-3PRGD2 SPECT/CT can be used to diagnose the benign and malignant in the SPN.But integrated tomographic imaging is better.
出处
《浙江临床医学》
2021年第1期8-10,共3页
Zhejiang Clinical Medical Journal
基金
内蒙古自治区自然科学基金资助项目(2018LH08028)。
