摘要
目的探讨地佐辛联合舒芬太尼用于食管癌根治术术后镇痛的临床疗效。方法选择食管癌根治术的食管癌患者98例,随机分为2组。对照组49例,患者接受舒芬太尼术后镇痛;观察组49例,患者接受地佐辛联合舒芬太尼术后镇痛。比较2组患者术后镇痛VAS评分以及镇静Ramsay评分以及术后使用镇痛泵的有效按压次数。分别检测2组患者手术前后的炎性因子的含量水平;记录2组患者手术后不良反应的发生情况,并进行统计学分析。结果观察组患者术后6 h、12 h及24 h时的VAS疼痛评分显著低于对照组(P<0.05);观察组术后2 h、6 h、12 h及24 h时的Ramsay镇静评分显著低于对照组(P<0.05);观察组术后48 h内使用镇痛泵的有效按压次数显著少于对照组(P<0.05)。观察组患者术后的白介素-6(IL-6)含量显著低于对照组(P<0.05);术后24 h及术后48 h的白介素-10(IL-10)含量水平显著高于对照组(P<0.05)。观察组术后发生皮肤瘙痒、呼吸抑制、嗜睡及恶心呕吐等不良事件的发生率显著低于对照组(P<0.05)。结论地佐辛辅佐舒芬太尼用于食管癌根治术患者术后镇痛,可有效提高术后镇痛疗效,降低患者术后发生炎症应激反应的程度,降低不良事件的发生率。
Objective To investigate the clinical efficacy of dizocine combined with sufentanil in analgesia after radical resection of esophageal cancer.Methods 98 cases of patients with esophageal cancer who underwent radical resection were randomly divided into 2 groups:the control group(n=49)and the observation group(n=49).The control group received postoperative analgesia with sufentanil,and the observation group received postoperative analgesia with dizocine combined with sufentanil.The postoperative analgesic VAS score,the postoperative analgesic Ramsay score,and the effective compressions of the analgesic pump were compared.The levels of inflammatory factors before and after surgery were detected in the 2 groups.The incidence of adverse reactions after surgery was recorded in both groups.Results The VAS pain scores of patients in the observation group at 6 h,12 h and 24 h after surgery were significantly lower than those of the control group(P<0.05).The Ramsay sedative score of the observation group at 2 h,6 h,12 h and 24 h after surgery was significantly lower than that of the control group(P<0.05);The number of effective compressions using analgesic pump in the observation group with in 48 h after surgery was significantly less than that of the control group(P<0.05).The interleukin-6(IL-6)level in the observation group was significantly lower than that of the control group(P<0.05);The level of interleukin-10(il-10)in the observation group was significantly higher than that of the control group 24 h and 48 h after surgery(P<0.05);The incidence of postoperative skin itching,respiratory depression,drowsiness,nausea and vomiting and other adverse events in the observation group was significantly lower than that of the control group(P<0.05).Conclusion Dizocine assisted with sufentanil for postoperative analgesia of patients with esophageal cancer after radical resection can effectively improve the postoperative analgesic effects of patients,which is conducive to reducing the degree of postoperative inflammatory stress r
作者
臧波
范捷
韩春芝
ZANG Bo;FAN Jie;HAN Chunzhi(Kaifeng People's Hospital,Kaifeng,475000)
出处
《实用癌症杂志》
2021年第1期80-83,95,共5页
The Practical Journal of Cancer
关键词
地佐辛
舒芬太尼
食管癌根治术
炎性因子
疗效
Dizocine
Sufentanil
Radical resection of esophageal cancer
Inflammatory factors
Curative effect
