摘要
总结95例复发难治性B细胞淋巴瘤患者接受以CD19为靶点的嵌合抗原受体T细胞治疗所致不良反应的护理经验。护理要点包括:密切监测及时发现CAR-T治疗患者生命体征及血液学指标变化;专科护理评估尽早识别中枢神经系统不良反应;做好细胞因子释放综合征和CAR-T治疗相关性脑病患者的症状管理以及特殊用药的护理等。本组病例除1例患者因多器官功能衰竭死亡外,其余患者的不良反应均得到有效控制,顺利出院。
This paper summarized the experience of providing care for 95 patients with relapsed refractory B-cell lymphoma who received chimeric antigen receptor T cell therapy targeting CD19 and showed adverse reactions.The key points of nursing care included close monitoring and timely detection of the changes of vital signs and hematological indicators of CAR-T patients,specialized nursing assessment for early identification of adverse reactions of the central nervous system,sound symptom management of those patients with cytokine release syndrome and CAR-T treatment related encephalopathy,and care for special medications.With the exception of one patient who died of multiple organ failure,the adverse reactions of the other patients were effectively controlled and discharged from hospital successfully.
作者
曾纯
陆宇晗
马淑玲
应志涛
ZENG Chun;LU Yuhan;MA Shuling;YING Zhitao(Department of Lyphoma,Beijing Cancer Hospital,Beijing Institute for Cancer Research,Beijing 100142,China;Department of Nursing,Beijing Cancer Hospital,Beijing Institute for Cancer Research)
出处
《解放军护理杂志》
CSCD
北大核心
2021年第1期80-83,共4页
Nursing Journal of Chinese People's Liberation Army
